EDAR
Tumor necrosis factor receptor superfamily member EDAR
Protein Summary
Receptor for EDA isoform A1, but not for EDA isoform A2. Mediates the activation of NF-kappa-B and JNK. May promote caspase-independent cell death. This gene encodes a member of the tumor necrosis factor receptor family. The encoded transmembrane protein is a receptor for the soluble ligand ectodysplasin A, and can activate the nuclear factor-kappaB, JNK, and caspase-independent cell death pathways. It is required for the development of hair, teeth, and other ectodermal derivatives. Mutations in this gene result in autosomal dominant and recessive forms of hypohidrotic ectodermal dysplasia. [provided by RefSeq, Jul 2008]
- ENST00000258443
- ENSP00000258443
- ENSG00000135960
- ENST00000376651
- ENSP00000365839
- ENST00000409271
- ENSP00000386371
- DL
- DL
- ED3
- ED5
- ED1R
- EDA3
- HRM1
- EDA1R
- ECTD10A
- ECTD10B
- EDA-A1R
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
|---|---|---|---|
cell type or tissue | 0.64 | ||
microRNA | 0.63 | ||
gene perturbation | 0.62 | ||
phenotype | 0.61 | ||
biological process | 0.59 | ||
Protein Classes
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 292.94 (req: < 5)
Gene RIFs: 49 (req: <= 3)
Antibodies: 289 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 292.94 (req: >= 5)
Gene RIFs: 49 (req: > 3)
Antibodies: 289 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 14
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligand: 0
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drug: 0