EDA2R
Tumor necrosis factor receptor superfamily member 27
Protein Summary
Receptor for EDA isoform A2, but not for EDA isoform A1. Mediates the activation of the NF-kappa-B and JNK pathways. Activation seems to be mediated by binding to TRAF3 and TRAF6. The protein encoded by this gene is a type III transmembrane protein of the TNFR (tumor necrosis factor receptor) superfamily, and contains cysteine-rich repeats and a single transmembrane domain. This protein binds to the EDA-A2 isoform of ectodysplasin, which plays an important role in maintenance of hair and teeth. Alternatively spliced transcript variants encodes distinct protein isoforms. [provided by RefSeq, Apr 2016]
- ENST00000253392
- ENSP00000253392
- ENSG00000131080
- ENST00000374719
- ENSP00000363851
- ENST00000396050
- ENSP00000379365
- ENST00000451436
- ENSP00000415242
- TNFRSF27
- XEDAR
- XEDAR
- EDAA2R
- EDA-A2R
- TNFRSF27
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
|---|---|---|---|
gene perturbation | 0.88 | ||
tissue sample | 0.63 | ||
biological process | 0.6 | ||
microRNA | 0.5 | ||
biological term | 0.41 | ||
Protein Classes
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 33.89 (req: < 5)
Gene RIFs: 23 (req: <= 3)
Antibodies: 310 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 33.89 (req: >= 5)
Gene RIFs: 23 (req: > 3)
Antibodies: 310 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 10
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligand: 0
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drug: 0