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Tbio
EDA
Ectodysplasin-A

Protein Summary
Description
Cytokine which is involved in epithelial-mesenchymal signaling during morphogenesis of ectodermal organs. Functions as a ligand activating the DEATH-domain containing receptors EDAR and EDA2R (PubMed:8696334, PubMed:11039935, PubMed:27144394). May also play a role in cell adhesion (By similarity). Isoform 1: Binds only to the receptor EDAR, while isoform 3 binds exclusively to the receptor EDA2R. Isoform 3: Binds only to the receptor EDA2R. The protein encoded by this gene is a type II membrane protein that can be cleaved by furin to produce a secreted form. The encoded protein, which belongs to the tumor necrosis factor family, acts as a homotrimer and may be involved in cell-cell signaling during the development of ectodermal organs. Defects in this gene are a cause of ectodermal dysplasia, anhidrotic, which is also known as X-linked hypohidrotic ectodermal dysplasia. Several transcript variants encoding many different isoforms have been found for this gene. [provided by RefSeq, Jul ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000338901
  • ENSP00000340611
  • ENSG00000158813
  • ENST00000374552
  • ENSP00000363680
  • ENST00000374553
  • ENSP00000363681
  • ENST00000524573
  • ENSP00000432585
  • ENST00000525810
  • ENSP00000434195
  • ENST00000527388
  • ENSP00000434861

Symbol
  • ED1
  • EDA2
  • ED1
  • HED
  • EDA1
  • EDA2
  • HED1
  • ODT1
  • XHED
  • ECTD1
  • XLHED
  • ED1-A1
  • ED1-A2
  • EDA-A1
  • EDA-A2
  • TNLG7C
  • STHAGX1
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
disease perturbation
0.83
biological process
0.75
cellular component
0.73
phenotype
0.66
biological term
0.63


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 350.34   (req: < 5)
Gene RIFs: 71   (req: <= 3)
Antibodies: 489   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 350.34   (req: >= 5)
Gene RIFs: 71   (req: > 3)
Antibodies: 489   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 21
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0