Protein Summary
Cytokine which is involved in epithelial-mesenchymal signaling during morphogenesis of ectodermal organs. Functions as a ligand activating the DEATH-domain containing receptors EDAR and EDA2R (PubMed:8696334, PubMed:11039935, PubMed:27144394). May also play a role in cell adhesion (By similarity). Isoform 1: Binds only to the receptor EDAR, while isoform 3 binds exclusively to the receptor EDA2R. Isoform 3: Binds only to the receptor EDA2R. The protein encoded by this gene is a type II membrane protein that can be cleaved by furin to produce a secreted form. The encoded protein, which belongs to the tumor necrosis factor family, acts as a homotrimer and may be involved in cell-cell signaling during the development of ectodermal organs. Defects in this gene are a cause of ectodermal dysplasia, anhidrotic, which is also known as X-linked hypohidrotic ectodermal dysplasia. Several transcript variants encoding many different isoforms have been found for this gene. [provided by RefSeq, Jul ...more
- ENST00000338901
- ENSP00000340611
- ENSG00000158813
- ENST00000374552
- ENSP00000363680
- ENST00000374553
- ENSP00000363681
- ENST00000524573
- ENSP00000432585
- ENST00000525810
- ENSP00000434195
- ENST00000527388
- ENSP00000434861
- ED1
- EDA2
- ED1
- HED
- EDA1
- EDA2
- HED1
- ODT1
- XHED
- ECTD1
- XLHED
- ED1-A1
- ED1-A2
- EDA-A1
- EDA-A2
- TNLG7C
- STHAGX1
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
|---|---|---|---|
disease perturbation | 0.83 | ||
biological process | 0.75 | ||
cellular component | 0.73 | ||
phenotype | 0.66 | ||
biological term | 0.63 | ||
Protein Classes
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 281.96 (req: < 5)
Gene RIFs: 71 (req: <= 3)
Antibodies: 489 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 281.96 (req: >= 5)
Gene RIFs: 71 (req: > 3)
Antibodies: 489 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 21
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligand: 0
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drug: 0
Expression Data (0 Tissues)
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
Active Ligands (0)
Protein-Protein Interactions (120)
P3H2
Family: Enzyme
Novelty: 0.04237396
p_int: 0.999977156
p_ni: 0.000017498
p_wrong: 0.000005346
Data Source: BioPlex
AP3B2
Novelty: 0.11897342
p_int: 0.999972391
p_ni: 0.000027608
p_wrong: 1e-9
Score: 0.51
Data Source: BioPlex,STRINGDB
P4HA1
Family: Enzyme
Novelty: 0.01624726
p_int: 0.999913375
p_ni: 0.000077474
p_wrong: 0.000009151
Data Source: BioPlex
AP3M2
Novelty: 0.18164255
p_int: 0.999697945
p_ni: 0.000301916
p_wrong: 1.39e-7
Score: 0.307
Data Source: BioPlex,STRINGDB
LNPK
Novelty: 0.07736762
p_int: 0.999463238
p_ni: 0.000536762
Score: 0.328
Data Source: BioPlex,STRINGDB
CXXC1
Family: Epigenetic
Novelty: 0.01019251
p_int: 0.998605393
p_ni: 0.001394604
p_wrong: 3e-9
Data Source: BioPlex
Nearest Tclin Targets
Pathways (66)
Reactome (4)
KEGG (2)
WikiPathways (60)
Click on a row in the table to change the structure displayed.
Data Source | Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|---|
Reactome | Cytokine Signaling in Immune system | ||||
Reactome | Immune System | ||||
Reactome | TNFR2 non-canonical NF-kB pathway | ||||
Reactome | TNFs bind their physiological receptors | ||||
Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|
Cytokine Signaling in Immune system | ||||
Immune System | ||||
TNFR2 non-canonical NF-kB pathway | ||||
TNFs bind their physiological receptors | ||||
Viral Interactions (0)
Gene Ontology Terms (32)
Functions (4)
Components (11)
Processes (17)
GO Term | Evidence | Assigned by | ||
|---|---|---|---|---|
Inferred from Direct Assay (IDA) | UniProtKB | |||
Inferred from Direct Assay (IDA) | HGNC | |||
Inferred from Mutant Phenotype (IMP) | UniProtKB | |||
Inferred from Electronic Annotation (IEA) | InterPro | |||
Disease Associations (null)
GWAS Traits (7)
Items per page:
1 – 5 of 7
GWAS Trait | EFO ID | Study Count | SNP Count | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
|---|---|---|---|---|---|---|---|---|---|
synophrys measurement | 1 | 1 | 1 | 81.5 | |||||
balding measurement | 1 | 1 | 1 | 64.9 | |||||
chronotype measurement | 1 | 1 | 1 | 31.3 | |||||
tooth eruption | 1 | 1 | 1 | 24.2 | |||||
odontogenesis | 1 | 1 | 1 | 17.6 | |||||
Items per page:
1 – 5 of 7
GWAS Trait | EFO ID | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
|---|---|---|---|---|---|---|---|
synophrys measurement | 1 | 81.5 | |||||
balding measurement | 1 | 64.9 | |||||
chronotype measurement | 1 | 31.3 | |||||
tooth eruption | 1 | 24.2 | |||||
odontogenesis | 1 | 17.6 | |||||
Find similar targets by:
IDG Resources
Orthologs (10)
1 – 5 of 10
Species | Name | Source ID | Gene ID | OMA | EggNOG | Inparanoid | ||
|---|---|---|---|---|---|---|---|---|
Chimp | ectodysplasin A | 101058344 | ||||||
Macaque | ectodysplasin-A | 694110 | ||||||
Mouse | MGI:1195272 | 13607 | ||||||
Rat | RGD:1563178 | 302424 | ||||||
Dog | ectodysplasin A | VGNC:54136 | 491935 | |||||
Species | Name | OMA | EggNOG | Inparanoid | ||
|---|---|---|---|---|---|---|
Chimp | ectodysplasin A | |||||
Macaque | ectodysplasin-A | |||||
Mouse | ||||||
Rat | ||||||
Dog | ectodysplasin A | |||||
Publication Statistics
PubMed Score 281.96
PubMed score by year
PubTator Score 1177.04
PubTator score by year
Related Publications
GeneRif Annotations (71)
Items per page:
0 of 0
PMID | Text |
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