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Tdark
ECT2L
Epithelial cell-transforming sequence 2 oncogene-like

Protein Summary
Description
May act as a guanine nucleotide exchange factor (GEF).
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000367682
  • ENSP00000356655
  • ENSG00000203734
  • ENST00000423192
  • ENSP00000387388
  • ENST00000541398
  • ENSP00000442307

Symbol
  • C6orf91
  • LFDH
  • LFDH
  • FBXO49
  • C6orf91
  • ARHGEF32
  • dJ509I19.2
  • dJ509I19.3
  • dJ509I19.5
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
cell type or tissue
0.88
cellular component
0.64
tissue sample
0.63
cell line
0.56
histone modification site profile
0.54


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 2.04   (req: < 5)
Gene RIFs: 1   (req: <= 3)
Antibodies: 65   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 2.04   (req: >= 5)
Gene RIFs: 1   (req: > 3)
Antibodies: 65   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 2
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (60)
DGKZ
Tchem
Family:  Enzyme
Novelty:  0.01312044
p_int:  0.946870389
p_ni:  0.001822965
p_wrong:  0.051306646
Data Source:  BioPlex
ZNF436
Tbio
Family:  TF
Novelty:  0.00892449
p_int:  0.887574367
p_ni:  0.005288437
p_wrong:  0.107137195
Data Source:  BioPlex
GSTM3
Tbio
Family:  Enzyme
Novelty:  0.0078192
p_int:  0.851101914
p_ni:  0.002888828
p_wrong:  0.146009259
Score:  0.379
Data Source:  BioPlex,STRINGDB
FBXO47
Tbio
Novelty:  0.26075359
Score:  0.759
Data Source:  STRINGDB
FBXO48
Tdark
Novelty:  0.53197799
Score:  0.758
Data Source:  STRINGDB
GLB1L2
Tdark
Family:  Enzyme
Novelty:  1.03866932
Score:  0.735
Data Source:  STRINGDB
FBXL6
Tdark
Novelty:  0.33416595
Score:  0.73
Data Source:  STRINGDB
FBXO36
Tdark
Novelty:  1.95826259
Score:  0.71
Data Source:  STRINGDB
CDRT1
Tdark
Novelty:  0.15731986
Score:  0.677
Data Source:  STRINGDB
LMO7
Tbio
Novelty:  0.03508141
Score:  0.655
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (0)
No pathways found
Viral Interactions (0)
No viral interactions found
Disease Associations (null)
No disease associations found
GWAS Traits (11)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
corneal resistance factor
1
1
1
57.8
central corneal thickness
1
1
0
3
40.1
type 2 diabetes mellitus
1
1
0
1
37.4
albumin:globulin ratio measurement
1
1
1
16.8
high density lipoprotein cholesterol measurement
1
1
1
16.8
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
corneal resistance factor
1
57.8
central corneal thickness
0
3
40.1
type 2 diabetes mellitus
0
1
37.4
albumin:globulin ratio measurement
1
16.8
high density lipoprotein cholesterol measurement
1
16.8
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (8)
1 – 5 of 8
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
epithelial cell transforming 2 like
VGNC:2772
463030
Mouse
MGI:3641723
100045792
Rat
RGD:9246970
103689991
Horse
epithelial cell transforming 2 like
VGNC:17413
100067883
Cow
epithelial cell transforming 2 like
VGNC:28315
100141063
Species
Name
OMA
EggNOG
Inparanoid
Chimp
epithelial cell transforming 2 like
Mouse
Rat
Horse
epithelial cell transforming 2 like
Cow
epithelial cell transforming 2 like
Publication Statistics
PubMed Score 2.04
PubMed score by year
PubTator Score 0.05
PubTator score by year
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Related Publications
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PMID
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