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Tbio
ECSCR
Endothelial cell-specific chemotaxis regulator

Protein Summary
Description
Regulates endothelial chemotaxis and tube formation. Has a role in angiogenesis and apoptosis via modulation of the actin cytoskeleton and facilitation of proteasomal degradation of the apoptosis inhibitors BIRC3/IAP1 and BIRC2/IAP2. The protein encoded by this gene is primarily found in endothelial cells and blood vessels, where it is involved in cell shape changes and EGF-induced cell migration. It can enhance the activation of vascular endothelial growth factor receptor-2/kinase insert domain receptor and also promote the proteolysis of internalized kinase insert domain receptor. This gene may play a role in angiogenesis-related diseases. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jun 2014]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000618155
  • ENSP00000479243
  • ENSG00000249751

Symbol
  • ECSM2
  • ARIA
  • ECSM2
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
gene perturbation
0.83
tissue sample
0.5
cell line
0.44
disease
0.41
tissue
0.4


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 12.58   (req: < 5)
Gene RIFs: 8   (req: <= 3)
Antibodies: 96   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 12.58   (req: >= 5)
Gene RIFs: 8   (req: > 3)
Antibodies: 96   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 7
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (33)
DUPD1
Tbio
Family:  Enzyme
Novelty:  0.2115789
p_int:  0.999995028
p_ni:  0.000004947
p_wrong:  2.5e-8
Data Source:  BioPlex
GALNT10
Tchem
Family:  Enzyme
Novelty:  0.065869
p_int:  0.999888839
p_ni:  0.000029529
p_wrong:  0.000081632
Data Source:  BioPlex
SOAT1
Tchem
Family:  Enzyme
Novelty:  0.00530755
p_int:  0.999803342
p_ni:  0.000196658
Data Source:  BioPlex
VMA21
Tdark
Family:  Enzyme
Novelty:  0.46129032
p_int:  0.999413497
p_ni:  0.000586455
p_wrong:  4.7e-8
Data Source:  BioPlex
RABGAP1
Tbio
Family:  Enzyme
Novelty:  0.14270101
p_int:  0.998903674
p_ni:  0.001096326
Data Source:  BioPlex
ZDHHC6
Tbio
Family:  Enzyme
Novelty:  0.17384821
p_int:  0.998438285
p_ni:  0.001561331
p_wrong:  3.84e-7
Data Source:  BioPlex
RAB4A
Tbio
Family:  Enzyme
Novelty:  0.00423197
p_int:  0.991070138
p_ni:  0.008923704
p_wrong:  0.000006158
Data Source:  BioPlex
B7ZAP0
Tbio
Family:  Enzyme
Novelty:  0.2377644
p_int:  0.940617867
p_ni:  0.059368725
p_wrong:  0.000013408
Data Source:  BioPlex
TMEM205
Tdark
Novelty:  0.41048198
p_int:  0.924554588
p_ni:  0.075440196
p_wrong:  0.000005216
Data Source:  BioPlex
ATP6V0C
Tbio
Family:  Enzyme
Novelty:  0.01142874
p_int:  0.858579233
p_ni:  0.141382242
p_wrong:  0.000038525
Data Source:  BioPlex
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (0)
No pathways found
Viral Interactions (0)
No viral interactions found
Disease Associations (null)
No disease associations found
GWAS Traits (11)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
vitamin C measurement
1
1
1
86.9
1
1
0
1.2
72.1
viral load
1
1
1
66.8
electrocardiography
1
1
4
62.1
reticulocyte count
1
1
1
49.5
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
vitamin C measurement
1
86.9
0
1.2
72.1
viral load
1
66.8
electrocardiography
4
62.1
reticulocyte count
1
49.5
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs
No orthologs found
Publication Statistics
PubMed Score 12.58
PubMed score by year
PubTator Score 356.17
PubTator score by year
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Related Publications
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PMID
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