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Tbio
ECPAS
Proteasome adapter and scaffold protein ECM29

Protein Summary
Description
Adapter/scaffolding protein that binds to the 26S proteasome, motor proteins and other compartment specific proteins. May couple the proteasome to different compartments including endosome, endoplasmic reticulum and centrosome. May play a role in ERAD and other enhanced proteolyis (PubMed:15496406). Promotes proteasome dissociation under oxidative stress (By similarity).
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000338205
  • ENSP00000339889
  • ENSG00000136813

Symbol
  • ECM29
  • KIAA0368
  • ECM29
  • KIAA0368
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
biological process
0
biological term
0
cell line
0
cell type or tissue
0
cellular component
0


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 24.55   (req: < 5)
Gene RIFs: 6   (req: <= 3)
Antibodies: 41   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 24.55   (req: >= 5)
Gene RIFs: 6   (req: > 3)
Antibodies: 41   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 4
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (3)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (116)
CYP2J2
Tchem
Novelty:  0.00534181
p_int:  0.999996236
p_ni:  0.000003764
Data Source:  BioPlex
NPY2R
Tchem
Family:  GPCR
Novelty:  0.01177255
p_int:  0.999507116
p_ni:  0.000492884
Data Source:  BioPlex
SLC2A9
Tbio
Family:  Transporter
Novelty:  0.00683926
p_int:  0.995858201
p_ni:  0.004141799
Data Source:  BioPlex
CMTM8
Tbio
Novelty:  0.0953768
p_int:  0.995342534
p_ni:  0.004657466
Data Source:  BioPlex
BSG
Tbio
Novelty:  0.0010285
p_int:  0.994084477
p_ni:  0.005915523
Data Source:  BioPlex
SLC39A9
Tbio
Family:  Transporter
Novelty:  0.06143625
p_int:  0.993398584
p_ni:  0.006601416
Data Source:  BioPlex
ARL2BP
Tbio
Novelty:  0.03460574
p_int:  0.98299602
p_ni:  0.01700398
Data Source:  BioPlex
IL13RA2
Tbio
Novelty:  0.03465642
p_int:  0.976910932
p_ni:  0.023089068
Data Source:  BioPlex
TMEM267
Tdark
Novelty:  3.50142721
p_int:  0.976310091
p_ni:  0.023689909
Score:  0.239
Data Source:  BioPlex,STRINGDB
CYB5B
Tbio
Novelty:  0.09395308
p_int:  0.974576967
p_ni:  0.025423033
Data Source:  BioPlex
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (0)
No pathways found
Viral Interactions (0)
No viral interactions found
Disease Associations (null)
No disease associations found
GWAS Traits (6)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
age at menarche
4
5
3
2.6
91.7
puberty onset measurement
2
2
3
76.6
body height
1
1
1
72.9
reticulocyte measurement
2
2
2
38.7
apolipoprotein A 1 measurement
1
1
1
33.1
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
age at menarche
3
2.6
91.7
puberty onset measurement
3
76.6
body height
1
72.9
reticulocyte measurement
2
38.7
apolipoprotein A 1 measurement
1
33.1
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (15)
1 – 5 of 15
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
Ecm29 proteasome adaptor and scaffold
VGNC:4771
464656
Macaque
KIAA0368 ortholog
712169
Mouse
MGI:2140220
230249
Rat
RGD:1306148
313196
Dog
Ecm29 proteasome adaptor and scaffold
VGNC:42346
100687244
Species
Name
OMA
EggNOG
Inparanoid
Chimp
Ecm29 proteasome adaptor and scaffold
Macaque
KIAA0368 ortholog
Mouse
Rat
Dog
Ecm29 proteasome adaptor and scaffold
Publication Statistics
PubMed Score 24.55
PubMed score by year
PubTator Score 10.50
PubTator score by year
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Related Publications
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PMID
Year
Title