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Tdark
ECHDC2
Enoyl-CoA hydratase domain-containing protein 2, mitochondrial

Protein Summary
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000358358
  • ENSP00000351125
  • ENSG00000121310
  • ENST00000371522
  • ENSP00000360577
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
kinase perturbation
0.93
transcription factor perturbation
0.88
virus perturbation
0.76
PubMedID
0.72
tissue sample
0.65


Protein Classes
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 3.12   (req: < 5)
Gene RIFs: 0   (req: <= 3)
Antibodies: 91   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 3.12   (req: >= 5)
Gene RIFs: 0   (req: > 3)
Antibodies: 91   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 2
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
No expression data found
Related Tools
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (54)
AUH
Tbio
Family:  Enzyme
Novelty:  0.01698227
p_int:  0.999999999
p_ni:  1e-9
Score:  0.276
Data Source:  BioPlex,STRINGDB
NDUFS6
Tclin
Family:  Enzyme
Novelty:  0.07910252
p_int:  0.997344508
p_ni:  0.002655447
p_wrong:  4.5e-8
Score:  0.183
Data Source:  BioPlex,STRINGDB
ALAS1
Tclin
Family:  Enzyme
Novelty:  0.00965779
p_int:  0.990057531
p_ni:  0.00974913
p_wrong:  0.000193339
Score:  0.616
Data Source:  BioPlex,STRINGDB
DNLZ
Tdark
Novelty:  0.10113346
p_int:  0.982476744
p_ni:  0.017523253
p_wrong:  3e-9
Score:  0.226
Data Source:  BioPlex,STRINGDB
SLIRP
Tbio
Novelty:  0.04630917
p_int:  0.934593497
p_ni:  0.065406502
p_wrong:  1e-9
Score:  0.252
Data Source:  BioPlex,STRINGDB
MMAB
Tbio
Family:  Enzyme
Novelty:  0.01681296
p_int:  0.851327034
p_ni:  0.147742126
p_wrong:  0.000930839
Score:  0.188
Data Source:  BioPlex,STRINGDB
CTU1
Tbio
Novelty:  0.04670058
p_int:  0.832487707
p_ni:  0.167511004
p_wrong:  0.000001289
Score:  0.167
Data Source:  BioPlex,STRINGDB
TOP3A
Tbio
Family:  Enzyme
Novelty:  0.0055546
p_int:  0.806085091
p_ni:  0.193449579
p_wrong:  0.00046533
Score:  0.22
Data Source:  BioPlex,STRINGDB
HADH
Tbio
Family:  Enzyme
Novelty:  0.00368073
Score:  0.875
Data Source:  STRINGDB
HACL1
Tbio
Family:  Enzyme
Novelty:  0.05302548
Score:  0.762
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Viral Interactions (0)
No viral interactions found
Disease Associations ()
No disease associations found
GWAS Traits (6)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
hematocrit
3
2
3
89
monocyte count
2
2
2
83.4
hemoglobin measurement
2
2
2
82.7
red blood cell density measurement
1
1
1
67.9
mean reticulocyte volume
1
1
1
61
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
hematocrit
3
89
monocyte count
2
83.4
hemoglobin measurement
2
82.7
red blood cell density measurement
1
67.9
mean reticulocyte volume
1
61
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (12)
1 – 5 of 12
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
enoyl-CoA hydratase domain containing 2
VGNC:10608
737617
Macaque
enoyl-CoA hydratase domain containing 2
713797
Mouse
MGI:1289238
52430
Rat
RGD:1308525
298381
Horse
enoyl-CoA hydratase domain containing 2
VGNC:17406
100061450
Species
Name
OMA
EggNOG
Inparanoid
Chimp
enoyl-CoA hydratase domain containing 2
Macaque
enoyl-CoA hydratase domain containing 2
Mouse
Rat
Horse
enoyl-CoA hydratase domain containing 2
Publication Statistics
PubMed Score 3.12
PubMed score by year
PubTator Score 0.11
PubTator score by year
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Related Publications
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PMID
Year
Title