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Tbio
ECHDC1
Ethylmalonyl-CoA decarboxylase

Protein Summary
Description
Decarboxylases ethylmalonyl-CoA decarboxylase, a potentially toxic metabolite, to form butyryl-CoA, suggesting it might be involved in metabolite proofreading. Also has methylmalonyl-CoA decarboxylase activity at lower level.
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000368289
  • ENSP00000357272
  • ENSG00000093144
  • ENST00000368291
  • ENSP00000357274
  • ENST00000430841
  • ENSP00000402492
  • ENST00000454591
  • ENSP00000404866
  • ENST00000454859
  • ENSP00000401751
  • ENST00000474289
  • ENSP00000434908
  • ENST00000528402
  • ENSP00000436109
  • ENST00000531967
  • ENSP00000436585

Symbol
  • MMCD
  • HEL-S-76
  • dJ351K20.2
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
kinase perturbation
0.97
cell type or tissue
0.71
histone modification site profile
0.71
transcription factor binding site profile
0.71
transcription factor perturbation
0.68


Protein Classes
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 37.16   (req: < 5)
Gene RIFs: 5   (req: <= 3)
Antibodies: 128   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 37.16   (req: >= 5)
Gene RIFs: 5   (req: > 3)
Antibodies: 128   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 3
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (70)
AIFM2
Tbio
Novelty:  0.02882373
p_int:  0.959290695
p_ni:  0.040709305
Data Source:  BioPlex
IL13RA2
Tbio
Novelty:  0.03465642
p_int:  0.885176053
p_ni:  0.114823946
Score:  0.189
Data Source:  BioPlex,STRINGDB
MCEE
Tbio
Family:  Enzyme
Novelty:  0.03190645
Score:  0.96
Data Source:  STRINGDB
ACADM
Tbio
Family:  Enzyme
Novelty:  0.00548721
Score:  0.941
Data Source:  STRINGDB
ACSS2
Tchem
Family:  Enzyme
Novelty:  0.00448879
Score:  0.929
Data Source:  STRINGDB
ALDH6A1
Tbio
Family:  Enzyme
Novelty:  0.03785268
Score:  0.921
Data Source:  STRINGDB
HADH
Tbio
Family:  Enzyme
Novelty:  0.00368073
Score:  0.921
Data Source:  STRINGDB
ACSS1
Tbio
Family:  Enzyme
Novelty:  0.02003886
Score:  0.919
Data Source:  STRINGDB
ACSS3
Tbio
Family:  Enzyme
Novelty:  0.11246144
Score:  0.91
Data Source:  STRINGDB
DBT
Tbio
Family:  Enzyme
Novelty:  0.0070589
Score:  0.908
Data Source:  STRINGDB
Viral Interactions (0)
No viral interactions found
Disease Associations (null)
No disease associations found
GWAS Traits (26)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
BMI-adjusted hip circumference
4
6
9
93.7
1
1
0
1.1
92.1
high density lipoprotein cholesterol measurement
12
5
13
84.2
BMI-adjusted waist-hip ratio
2
5
10
83.2
triglyceride measurement
2
2
3
74.9
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
BMI-adjusted hip circumference
9
93.7
0
1.1
92.1
high density lipoprotein cholesterol measurement
13
84.2
BMI-adjusted waist-hip ratio
10
83.2
triglyceride measurement
3
74.9
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (13)
1 – 5 of 13
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
ethylmalonyl-CoA decarboxylase 1
VGNC:11065
745395
Macaque
ethylmalonyl-CoA decarboxylase 1
712072
Mouse
MGI:1277169
52665
Rat
RGD:1359654
361465
Dog
ethylmalonyl-CoA decarboxylase 1
VGNC:40185
609850
Species
Name
OMA
EggNOG
Inparanoid
Chimp
ethylmalonyl-CoA decarboxylase 1
Macaque
ethylmalonyl-CoA decarboxylase 1
Mouse
Rat
Dog
ethylmalonyl-CoA decarboxylase 1
Publication Statistics
PubMed Score 37.16
PubMed score by year
PubTator Score 8.75
PubTator score by year
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Related Publications
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PMID
Year
Title