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Tbio
ECH1
Delta(3,5)-Delta(2,4)-dienoyl-CoA isomerase, mitochondrial

Protein Summary
Description
Isomerization of 3-trans,5-cis-dienoyl-CoA to 2-trans,4-trans-dienoyl-CoA. This gene encodes a member of the hydratase/isomerase superfamily. The gene product shows high sequence similarity to enoyl-coenzyme A (CoA) hydratases of several species, particularly within a conserved domain characteristic of these proteins. The encoded protein, which contains a C-terminal peroxisomal targeting sequence, localizes to the peroxisome. The rat ortholog, which localizes to the matrix of both the peroxisome and mitochondria, can isomerize 3-trans,5-cis-dienoyl-CoA to 2-trans,4-trans-dienoyl-CoA, indicating that it is a delta3,5-delta2,4-dienoyl-CoA isomerase. This enzyme functions in the auxiliary step of the fatty acid beta-oxidation pathway. Expression of the rat gene is induced by peroxisome proliferators. [provided by RefSeq, Jul 2008]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000221418
  • ENSP00000221418
  • ENSG00000104823
  • ENST00000634245
  • ENSP00000489530
  • ENSG00000282853

Symbol
  • HPXEL
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
disease perturbation
1
kinase perturbation
0.95
interacting protein
0.93
transcription factor perturbation
0.91
histone modification site profile
0.83


Protein Classes
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 46.86   (req: < 5)
Gene RIFs: 4   (req: <= 3)
Antibodies: 247   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 46.86   (req: >= 5)
Gene RIFs: 4   (req: > 3)
Antibodies: 247   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 4
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
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TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (113)
ECI2
Tbio
Family:  Enzyme
Novelty:  0.02317646
p_int:  0.999999993
p_ni:  7e-9
Score:  0.854
Data Source:  BioPlex,STRINGDB
TRAF3
Tbio
Novelty:  0.0022525
p_int:  0.999998441
p_ni:  0.000001559
Score:  0.244
Data Source:  BioPlex,STRINGDB
MCCC2
Tbio
Family:  Enzyme
Novelty:  0.06681335
p_int:  0.998372367
p_ni:  0.001627633
Score:  0.567
Data Source:  BioPlex,STRINGDB
EIF2B3
Tbio
Novelty:  0.04963646
p_int:  0.995544983
p_ni:  0.004455017
Score:  0.203
Data Source:  BioPlex,STRINGDB
MCCC1
Tbio
Family:  Enzyme
Novelty:  0.01234441
p_int:  0.98732862
p_ni:  0.01267138
Score:  0.262
Data Source:  BioPlex,STRINGDB
FHL2
Tbio
Novelty:  0.00501273
p_int:  0.915248972
p_ni:  0.084750153
p_wrong:  8.75e-7
Score:  0.181
Data Source:  BioPlex,STRINGDB
IQGAP1
Tbio
Family:  Enzyme
Novelty:  0.00434481
p_int:  0.815335982
p_ni:  0.184664018
Score:  0.189
Data Source:  BioPlex,STRINGDB
HSD17B4
Tbio
Novelty:  0.00547499
Score:  0.987
Data Source:  STRINGDB
PECR
Tbio
Family:  Enzyme
Novelty:  0.01550165
Score:  0.97
Data Source:  STRINGDB
SCP2
Tchem
Novelty:  0.00183736
Score:  0.97
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (30)
Peroxisomal protein import (R-HSA-9033241)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 2 of 2
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Peroxisomal protein import
Reactome
Protein localization
Name
Explore in Pharos
Explore in Source
Peroxisomal protein import
Protein localization
Viral Interactions (0)
No viral interactions found
Disease Associations (null)
No disease associations found
GWAS Traits (16)
Items per page:
1 – 5 of 16
GWAS Trait
EFO ID
ENSG ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
blood protein measurement
2
2
2
83.2
blood protein measurement
2
2
2
83.2
SIR2-like protein 2 measurement
1
1
1
82.5
SIR2-like protein 2 measurement
1
1
1
82.5
platelet count
2
2
2
80.1
Items per page:
1 – 5 of 16
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
blood protein measurement
2
83.2
blood protein measurement
2
83.2
SIR2-like protein 2 measurement
1
82.5
SIR2-like protein 2 measurement
1
82.5
platelet count
2
80.1
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (12)
1 – 5 of 12
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
enoyl-CoA hydratase 1 [Source:HGNC Symbol;Acc:HGNC:3149]
Mouse
MGI:1858208
51798
Rat
RGD:69353
64526
Dog
enoyl-CoA hydratase 1
VGNC:40184
476467
Horse
enoyl-CoA hydratase 1
VGNC:17404
100066427
Species
Name
OMA
EggNOG
Inparanoid
Chimp
enoyl-CoA hydratase 1 [Source:HGNC Symbol;Acc:HGNC:3149]
Mouse
Rat
Dog
enoyl-CoA hydratase 1
Horse
enoyl-CoA hydratase 1
Publication Statistics
PubMed Score 46.86
PubMed score by year
PubTator Score 17.04
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title