Tbio ECH1 Delta(3,5)-Delta(2,4)-dienoyl-CoA isomerase, mitochondrial

Protein Summary

Description

Isomerization of 3-trans,5-cis-dienoyl-CoA to 2-trans,4-trans-dienoyl-CoA. This gene encodes a member of the hydratase/isomerase superfamily. The gene product shows high sequence similarity to enoyl-coenzyme A (CoA) hydratases of several species, particularly within a conserved domain characteristic of these proteins. The encoded protein, which contains a C-terminal peroxisomal targeting sequence, localizes to the peroxisome. The rat ortholog, which localizes to the matrix of both the peroxisome and mitochondria, can isomerize 3-trans,5-cis-dienoyl-CoA to 2-trans,4-trans-dienoyl-CoA, indicating that it is a delta3,5-delta2,4-dienoyl-CoA isomerase. This enzyme functions in the auxiliary step of the fatty acid beta-oxidation pathway. Expression of the rat gene is induced by peroxisome proliferators. [provided by RefSeq, Jul 2008]

Uniprot Accession IDs

• Q13011
• A8K745
• Q8WVX0
• Q96EZ9

Gene Name

• ECH1

Ensembl ID

• ENST00000221418
• ENSP00000221418
• ENSG00000104823
• ENST00000634245
• ENSP00000489530
• ENSG00000282853

Symbol

• HPXEL

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
disease perturbation	1
kinase perturbation	0.95
interacting protein	0.93
transcription factor perturbation	0.91
histone modification site profile	0.83

Protein Classes

PANTHER Classes

Protein / Transferase / Acyltransferase / Delta(3,5)-delta(2,4)-dienoyl-coa Isomerase, Mitochondrial

Protein / Transferase / Acetyltransferase / Delta(3,5)-delta(2,4)-dienoyl-coa Isomerase, Mitochondrial

Protein / Oxidoreductase / Dehydrogenase / Delta(3,5)-delta(2,4)-dienoyl-coa Isomerase, Mitochondrial

Protein / Lyase / Hydratase / Delta(3,5)-delta(2,4)-dienoyl-coa Isomerase, Mitochondrial

Protein / Ligase / Delta(3,5)-delta(2,4)-dienoyl-coa Isomerase, Mitochondrial

Protein / Isomerase / Epimerase/racemase / Delta(3,5)-delta(2,4)-dienoyl-coa Isomerase, Mitochondrial

DTO Classes

Protein / Enzyme / Isomerase / Epimerase/racemase / Delta(3,5)-delta(2,4)-dienoyl-coa Isomerase, Mitochondrial

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 46.86   (req: < 5)

Gene RIFs: 5   (req: <= 3)

Antibodies: 247   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 46.86   (req: >= 5)

Gene RIFs: 5   (req: > 3)

Antibodies: 247   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 4

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0