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Tbio
ECEL1
Endothelin-converting enzyme-like 1

Protein Summary
Description
May contribute to the degradation of peptide hormones and be involved in the inactivation of neuronal peptides. This gene encodes a member of the M13 family of endopeptidases. Members of this family are zinc-containing type II integral-membrane proteins that are important regulators of neuropeptide and peptide hormone activity. Mutations in this gene are associated with autosomal recessive distal arthrogryposis, type 5D. This gene has multiple pseudogenes on chromosome 2. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Mar 2014]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000304546
  • ENSP00000302051
  • ENSG00000171551
  • ENST00000409941
  • ENSP00000386333

Symbol
  • XCE
  • XCE
  • DA5D
  • DINE
  • ECEX
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
protein domain
0.73
PubMedID
0.66
tissue sample
0.63
cell type or tissue
0.57
disease
0.53


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 77.84   (req: < 5)
Gene RIFs: 7   (req: <= 3)
Antibodies: 42   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 77.84   (req: >= 5)
Gene RIFs: 7   (req: > 3)
Antibodies: 42   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 5
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
No expression data found
Related Tools
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (34)
TLR10
Tbio
Novelty:  0.00817239
p_int:  0.999993746
p_ni:  0.000006254
Data Source:  BioPlex
SCGB2A2
Tbio
Novelty:  0.01594053
p_int:  0.999908654
p_ni:  0.000091346
Data Source:  BioPlex
DNAJB9
Tbio
Novelty:  0.00536296
p_int:  0.99989276
p_ni:  0.00010724
Score:  0.152
Data Source:  BioPlex,STRINGDB
HLA-E
Tbio
Novelty:  0.00216583
p_int:  0.999670812
p_ni:  0.000329187
p_wrong:  1e-9
Data Source:  BioPlex
MPPE1
Tbio
Family:  Enzyme
Novelty:  0.16027847
p_int:  0.997381904
p_ni:  0.002618096
Data Source:  BioPlex
DNAJC30
Tdark
Novelty:  0.57178901
p_int:  0.996088359
p_ni:  0.003792228
p_wrong:  0.000119413
Data Source:  BioPlex
CLEC2D
Tbio
Novelty:  0.02501194
p_int:  0.993509492
p_ni:  0.006490507
p_wrong:  1e-9
Data Source:  BioPlex
CD1B
Tbio
Novelty:  0.00102701
p_int:  0.984975517
p_ni:  0.014929439
p_wrong:  0.000095044
Data Source:  BioPlex
IL17RC
Tclin
Novelty:  0.01844832
p_int:  0.972514308
p_ni:  0.022336453
p_wrong:  0.005149239
Data Source:  BioPlex
VNN2
Tbio
Novelty:  0.02286648
p_int:  0.972395548
p_ni:  0.027290554
p_wrong:  0.000313898
Data Source:  BioPlex
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Viral Interactions (0)
No viral interactions found
Disease Associations ()
No disease associations found
GWAS Traits (10)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
refractive error measurement
3
6
7
12.7
98.1
Myopia
3
2
0
1.3
86.9
corneal topography
2
1
2
83.9
age at onset
1
1
0
12.7
81.9
body height
1
1
1
68.8
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
refractive error measurement
7
12.7
98.1
Myopia
0
1.3
86.9
corneal topography
2
83.9
age at onset
0
12.7
81.9
body height
1
68.8
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (11)
1 – 5 of 11
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
endothelin converting enzyme like 1
VGNC:10773
460013
Macaque
endothelin-converting enzyme-like 1
721061
Mouse
MGI:1343461
13599
Rat
RGD:61806
60417
Dog
endothelin converting enzyme like 1
VGNC:40183
486161
Species
Name
OMA
EggNOG
Inparanoid
Chimp
endothelin converting enzyme like 1
Macaque
endothelin-converting enzyme-like 1
Mouse
Rat
Dog
endothelin converting enzyme like 1
Publication Statistics
PubMed Score 77.84
PubMed score by year
PubTator Score 43.61
PubTator score by year
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Related Publications
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PMID
Year
Title