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Tchem
ECE2
Endothelin-converting enzyme 2

Protein Summary
Description
Converts big endothelin-1 to endothelin-1. Also involved in the processing of various neuroendocrine peptides, including neurotensin, angiotensin I, substance P, proenkephalin-derived peptides, and prodynorphin-derived peptides. May play a role in amyloid-beta processing (By similarity).
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000357474
  • ENSP00000350066
  • ENSG00000145194
  • ENST00000359140
  • ENSP00000352052
  • ENST00000404464
  • ENSP00000385846

Symbol
  • KIAA0604
  • EEF1AKMT4
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
biological process
0
biological term
0
cell line
0
cell type or tissue
0
cellular component
0


Protein Classes
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 38.73   (req: < 5)
Gene RIFs: 10   (req: <= 3)
Antibodies: 0   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 38.73   (req: >= 5)
Gene RIFs: 10   (req: > 3)
Antibodies: 0   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 4
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 2
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Protein-Protein Interactions (40)
RCOR3
Tdark
Family:  TF
Novelty:  0.18886215
p_int:  0.996305947
p_ni:  0.003694053
Score:  0.211
Data Source:  BioPlex,STRINGDB
DHX40
Tdark
Family:  Enzyme
Novelty:  0.27906444
p_int:  0.99246903
p_ni:  0.00753097
Score:  0.394
Data Source:  BioPlex,STRINGDB
RCOR1
Tbio
Family:  TF
Novelty:  0.00644648
p_int:  0.946466671
p_ni:  0.053533329
Score:  0.252
Data Source:  BioPlex,STRINGDB
KDM1A
Tchem
Family:  Epigenetic
Novelty:  0.00142673
p_int:  0.849658959
p_ni:  0.150341041
Score:  0.232
Data Source:  BioPlex,STRINGDB
KCNIP4
Tbio
Family:  IC
Novelty:  0.00973829
p_int:  0.790896142
p_ni:  0.209103858
Score:  0.232
Data Source:  BioPlex,STRINGDB
EEF1AKMT2
Tbio
Family:  Enzyme
Novelty:  0.13586312
Score:  0.723
Data Source:  STRINGDB
EDN3
Tbio
Novelty:  0.00116752
Score:  0.686
Data Source:  STRINGDB
EDN2
Tbio
Novelty:  0.00203492
Score:  0.669
Data Source:  STRINGDB
IDE
Tchem
Family:  Enzyme
Novelty:  0.00207793
Score:  0.655
Data Source:  STRINGDB
EDN1
Tbio
Novelty:  0.00007453
Score:  0.65
Data Source:  Reactome,STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (6)
Class A/1 (Rhodopsin-like receptors) (R-HSA-373076)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 5 of 5
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Class A/1 (Rhodopsin-like receptors)
Reactome
GPCR ligand binding
Reactome
Peptide ligand-binding receptors
Reactome
Signal Transduction
Reactome
Signaling by GPCR
Name
Explore in Pharos
Explore in Source
Class A/1 (Rhodopsin-like receptors)
GPCR ligand binding
Peptide ligand-binding receptors
Signal Transduction
Signaling by GPCR
Viral Interactions (0)
No viral interactions found
Disease Associations (null)
No disease associations found
GWAS Traits (19)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
platelet crit
2
9
12
99.5
platelet count
5
9
15
99.4
appendicular lean mass
4
2
4
92.2
hematological measurement
1
1
1
84.2
mathematical ability
4
4
6
75.1
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
platelet crit
12
99.5
platelet count
15
99.4
appendicular lean mass
4
92.2
hematological measurement
1
84.2
mathematical ability
6
75.1
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (9)
1 – 5 of 9
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Rat
RGD:1303039
408243
Dog
endothelin converting enzyme 2
VGNC:40182
488105
Horse
endothelin converting enzyme 2
VGNC:17402
100059042
Cow
endothelin converting enzyme 2
VGNC:28303
281134
Pig
endothelin converting enzyme 2
100627224
Species
Name
OMA
EggNOG
Inparanoid
Rat
Dog
endothelin converting enzyme 2
Horse
endothelin converting enzyme 2
Cow
endothelin converting enzyme 2
Pig
endothelin converting enzyme 2
Publication Statistics
PubMed Score 38.73
PubMed score by year
PubTator Score 34.32
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title