ECE1
Endothelin-converting enzyme 1
Protein Summary
Converts big endothelin-1 to endothelin-1. The protein encoded by this gene is involved in proteolytic processing of endothelin precursors to biologically active peptides. Mutations in this gene are associated with Hirschsprung disease, cardiac defects and autonomic dysfunction. Alternatively spliced transcript variants encoding different isoforms have been noted for this gene.[provided by RefSeq, Sep 2009]
- ENST00000264205
- ENSP00000264205
- ENSG00000117298
- ENST00000357071
- ENSP00000349581
- ENST00000374893
- ENSP00000364028
- ENST00000415912
- ENSP00000405088
- ECE
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
|---|---|---|---|
cellular component | 0.9 | ||
ligand (protein) perturbation | 0.83 | ||
kinase perturbation | 0.76 | ||
transcription factor binding site profile | 0.74 | ||
protein domain | 0.73 | ||
Protein Classes
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 647.35 (req: < 5)
Gene RIFs: 82 (req: <= 3)
Antibodies: 377 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 647.35 (req: >= 5)
Gene RIFs: 82 (req: > 3)
Antibodies: 377 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 19
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligands: 259
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drug: 1