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Tbio
ECD
Protein ecdysoneless homolog

Protein Summary
Description
Regulator of p53/TP53 stability and function. Inhibits MDM2-mediated degradation of p53/TP53 possibly by cooperating in part with TXNIP (PubMed:16849563, PubMed:23880345). May be involved transcriptional regulation. In vitro has intrinsic transactivation activity enhanced by EP300. May be a transcriptional activator required for the expression of glycolytic genes (PubMed:19919181, PubMed:9928932). Involved in regulation of cell cycle progression. Proposed to disrupt Rb-E2F binding leading to transcriptional activation of E2F proteins (PubMed:19640839). The cell cycle -regulating function may depend on its RUVBL1-mediated association with the R2TP complex (PubMed:26711270). May play a role in regulation of pre-mRNA splicing (PubMed:24722212).
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000372979
  • ENSP00000362070
  • ENSG00000122882
  • ENST00000430082
  • ENSP00000401566
  • ENST00000454759
  • ENSP00000395786

Symbol
  • GCR2
  • SGT1
  • HSGT1
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
histone modification site profile
0.9
disease perturbation
0.87
transcription factor binding site profile
0.83
kinase perturbation
0.76
tissue sample
0.7


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 16.24   (req: < 5)
Gene RIFs: 7   (req: <= 3)
Antibodies: 147   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 16.24   (req: >= 5)
Gene RIFs: 7   (req: > 3)
Antibodies: 147   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 9
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (63)
TSSC4
Tdark
Novelty:  0.17064786
p_int:  0.999999959
p_ni:  4.1e-8
Score:  0.848
Data Source:  BioPlex,STRINGDB
EAPP
Tbio
Novelty:  0.06519266
p_int:  0.999995423
p_ni:  0.000004577
Score:  0.812
Data Source:  BioPlex,STRINGDB
AAR2
Tbio
Novelty:  0.05805748
p_int:  0.999980036
p_ni:  0.000019964
Score:  0.869
Data Source:  BioPlex,STRINGDB
SNRNP40
Tbio
Novelty:  0.16791896
p_int:  0.997842416
p_ni:  0.002157584
Score:  0.737
Data Source:  BioPlex,STRINGDB
MYH7
Tbio
Novelty:  0.00268092
p_int:  0.997256282
p_ni:  0.002538396
p_wrong:  0.000205323
Score:  0.185
Data Source:  BioPlex,STRINGDB
PNKD
Tbio
Family:  Enzyme
Novelty:  0.02456078
p_int:  0.994182092
p_ni:  0.005817907
Data Source:  BioPlex
KIAA1143
Tdark
Novelty:  3.96985921
p_int:  0.989476321
p_ni:  0.010523678
Score:  0.696
Data Source:  BioPlex,STRINGDB
GPBP1L1
Tdark
Novelty:  0.69320833
p_int:  0.989037891
p_ni:  0.010962109
Score:  0.165
Data Source:  BioPlex,STRINGDB
WDR83
Tbio
Novelty:  0.11602568
p_int:  0.988630191
p_ni:  0.011369797
p_wrong:  1.2e-8
Data Source:  BioPlex
GPR156
Tdark
Family:  GPCR
Novelty:  0.39183023
p_int:  0.973649183
p_ni:  0.026350817
Score:  0.207
Data Source:  BioPlex,STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Viral Interactions (0)
No viral interactions found
Disease Associations (null)
No disease associations found
GWAS Traits (2)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
glomerular filtration rate
1
1
1
50.6
body height
1
1
1
45.7
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
glomerular filtration rate
1
50.6
body height
1
45.7
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (14)
1 – 5 of 14
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Macaque
ecdysoneless cell cycle regulator
707699
Mouse
MGI:1917851
70601
Rat
RGD:1565023
688968
Dog
ecdysoneless cell cycle regulator
VGNC:40180
479244
Horse
ecdysoneless cell cycle regulator
VGNC:17400
100063816
Species
Name
OMA
EggNOG
Inparanoid
Macaque
ecdysoneless cell cycle regulator
Mouse
Rat
Dog
ecdysoneless cell cycle regulator
Horse
ecdysoneless cell cycle regulator
Publication Statistics
PubMed Score 16.24
PubMed score by year
PubTator Score 37.30
PubTator score by year
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Related Publications
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PMID
Year
Title