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Tbio
EBI3
Interleukin-27 subunit beta

Protein Summary
Description
Associates with IL27 to form the IL-27 interleukin, a heterodimeric cytokine which functions in innate immunity. IL-27 has pro- and anti-inflammatory properties, that can regulate T-helper cell development, suppress T-cell proliferation, stimulate cytotoxic T-cell activity, induce isotype switching in B-cells, and that has diverse effects on innate immune cells. Among its target cells are CD4 T-helper cells which can differentiate in type 1 effector cells (TH1), type 2 effector cells (TH2) and IL17 producing helper T-cells (TH17). It drives rapid clonal expansion of naive but not memory CD4 T-cells. It also strongly synergizes with IL-12 to trigger interferon-gamma/IFN-gamma production of naive CD4 T-cells, binds to the cytokine receptor WSX-1/TCCR. Another important role of IL-27 is its antitumor activity as well as its antiangiogenic activity with activation of production of antiangiogenic chemokines. This gene was identified by its induced expression in B lymphocytes in response Eps ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000221847
  • ENSP00000221847
  • ENSG00000105246

Symbol
  • IL27B
  • IL27B
  • IL35B
  • IL-27B
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
PubMedID
0.73
kinase perturbation
0.66
co-expressed gene
0.61
tissue sample
0.59
virus perturbation
0.59


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 9.13   (req: < 5)
Gene RIFs: 49   (req: <= 3)
Antibodies: 820   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 9.13   (req: >= 5)
Gene RIFs: 49   (req: > 3)
Antibodies: 820   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 12
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (25)
PRKCD
Tclin
Family:  Kinase
Novelty:  0.0009758
p_int:  0.999999989
p_ni:  1e-8
Data Source:  BioPlex
ZMYND19
Tdark
Novelty:  0.3590069
p_int:  0.96656753
p_ni:  0.033400186
p_wrong:  0.000032284
Data Source:  BioPlex
ZZEF1
Tdark
Novelty:  0.33216648
p_int:  0.945094064
p_ni:  0.054905936
Data Source:  BioPlex
ARMC8
Tbio
Novelty:  0.06820746
p_int:  0.92421841
p_ni:  0.07578159
Data Source:  BioPlex
HECTD3
Tdark
Family:  Enzyme
Novelty:  2.20874654
p_int:  0.901057525
p_ni:  0.098942475
Data Source:  BioPlex
MAEA
Tbio
Novelty:  0.00833813
p_int:  0.820800843
p_ni:  0.179199157
Data Source:  BioPlex
IL27
Tbio
Novelty:  0.01469348
Score:  0.984
Data Source:  Reactome,STRINGDB
IL12A
Tclin
Novelty:  0.05943184
Score:  0.975
Data Source:  Reactome,STRINGDB
IL27RA
Tbio
Novelty:  0.01348051
Score:  0.969
Data Source:  Reactome,STRINGDB
CANX
Tbio
Novelty:  0.00087002
Score:  0.935
Data Source:  Reactome,STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (7)
Cytokine Signaling in Immune system (R-HSA-1280215)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 5 of 6
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Cytokine Signaling in Immune system
Reactome
Immune System
Reactome
Interleukin-12 family signaling
Reactome
Interleukin-27 signaling
Reactome
Interleukin-35 Signalling
Name
Explore in Pharos
Explore in Source
Cytokine Signaling in Immune system
Immune System
Interleukin-12 family signaling
Interleukin-27 signaling
Interleukin-35 Signalling
Viral Interactions (0)
No viral interactions found
Disease Associations (null)
No disease associations found
GWAS Traits (5)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
blood protein measurement
1
1
1
91.9
interleukin-27 measurement
1
4
4
90.8
triglyceride measurement
3
2
3
58.5
apolipoprotein A 1 measurement
2
2
2
25.6
C-reactive protein measurement
1
1
1
0.5
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
blood protein measurement
1
91.9
interleukin-27 measurement
4
90.8
triglyceride measurement
3
58.5
apolipoprotein A 1 measurement
2
25.6
C-reactive protein measurement
1
0.5
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (11)
1 – 5 of 11
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
Epstein-Barr virus induced 3
737135
Mouse
MGI:1354171
50498
Rat
RGD:1589467
680609
Dog
Epstein-Barr virus induced 3
485043
Horse
Epstein-Barr virus induced 3
100063061
Species
Name
OMA
EggNOG
Inparanoid
Chimp
Epstein-Barr virus induced 3
Mouse
Rat
Dog
Epstein-Barr virus induced 3
Horse
Epstein-Barr virus induced 3
Publication Statistics
PubMed Score 9.13
PubMed score by year
PubTator Score 55.17
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title