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Tbio
EAPP
E2F-associated phosphoprotein

Protein Summary
Description
May play an important role in the fine-tuning of both major E2F1 activities, the regulation of the cell-cycle and the induction of apoptosis. Promotes S-phase entry, and inhibits p14(ARP) expression. This gene encodes a phosphoprotein that interacts with several members of the E2F family of proteins. The protein localizes to the nucleus, and is present throughout the cell cycle except during mitosis. It functions to modulate E2F-regulated transcription and stimulate proliferation. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2016]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000250454
  • ENSP00000250454
  • ENSG00000129518

Symbol
  • C14orf11
  • BM036
  • C14orf11
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
disease perturbation
0.87
cell type or tissue
0.79
transcription factor binding site profile
0.78
tissue sample
0.64
kinase perturbation
0.6


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 16.04   (req: < 5)
Gene RIFs: 4   (req: <= 3)
Antibodies: 119   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 16.04   (req: >= 5)
Gene RIFs: 4   (req: > 3)
Antibodies: 119   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 3
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
No expression data found
Related Tools
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (59)
TSSC4
Tdark
Novelty:  0.17064786
p_int:  0.999999998
p_ni:  2e-9
Score:  0.845
Data Source:  BioPlex,STRINGDB
AAR2
Tbio
Novelty:  0.05805748
p_int:  0.99999993
p_ni:  7e-8
Score:  0.91
Data Source:  BioPlex,STRINGDB
ECD
Tbio
Novelty:  0.06070487
p_int:  0.999995423
p_ni:  0.000004577
Score:  0.812
Data Source:  BioPlex,STRINGDB
DDX23
Tbio
Family:  Enzyme
Novelty:  0.03592096
p_int:  0.999878496
p_ni:  0.000121504
Score:  0.735
Data Source:  BioPlex,STRINGDB
CD2BP2
Tbio
Novelty:  0.01440995
p_int:  0.999550561
p_ni:  0.000449439
Score:  0.682
Data Source:  BioPlex,STRINGDB
SNRPB
Tbio
Novelty:  0.01503535
p_int:  0.999476126
p_ni:  0.000492292
p_wrong:  0.000031583
Score:  0.238
Data Source:  BioPlex,STRINGDB
SNRPN
Tbio
Novelty:  0.002157
p_int:  0.999208961
p_ni:  0.000777968
p_wrong:  0.000013072
Score:  0.551
Data Source:  BioPlex,STRINGDB
SNRPE
Tbio
Novelty:  0.02033423
p_int:  0.999111623
p_ni:  0.000888377
Score:  0.552
Data Source:  BioPlex,STRINGDB
LZTS2
Tbio
Novelty:  0.09515452
p_int:  0.998169794
p_ni:  0.001830149
p_wrong:  5.7e-8
Score:  0.519
Data Source:  BioPlex,STRINGDB
USB1
Tbio
Family:  Enzyme
Novelty:  0.01677996
p_int:  0.998103962
p_ni:  0.001895885
p_wrong:  1.53e-7
Score:  0.689
Data Source:  BioPlex,STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (0)
No pathways found
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (5)
Find Similar Targets
Items per page:
10
1 – 2 of 2
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
MGI
Inferred from Electronic Annotation (IEA)
UniProtKB-SubCell
Disease Associations ()
No disease associations found
GWAS Traits (1)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
self reported educational attainment
1
1
1
15.8
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
self reported educational attainment
1
15.8
IDG Resources
No IDG generated resources found
Orthologs (12)
1 – 5 of 12
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
E2F associated phosphoprotein
VGNC:8198
452852
Mouse
MGI:1913516
66266
Rat
RGD:1309624
299043
Dog
E2F associated phosphoprotein
490647
Horse
E2F associated phosphoprotein
VGNC:17393
100056916
Species
Name
OMA
EggNOG
Inparanoid
Chimp
E2F associated phosphoprotein
Mouse
Rat
Dog
E2F associated phosphoprotein
Horse
E2F associated phosphoprotein
Publication Statistics
PubMed Score 16.04
PubMed score by year
PubTator Score 24.84
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title