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Tbio
E4F1
Transcription factor E4F1

Protein Summary
Description
May function as a transcriptional repressor. May also function as a ubiquitin ligase mediating ubiquitination of chromatin-associated TP53. Functions in cell survival and proliferation through control of the cell cycle. Functions in the p53 and pRB tumor suppressor pathways and regulates the cyclin CCNA2 transcription. Identified as a cellular target of the adenoviral oncoprotein E1A, it is required for both transcriptional activation and repression of viral genes. The zinc finger protein encoded by this gene is one of several cellular transcription factors whose DNA-binding activities are regulated through the action of adenovirus E1A. A 50-kDa amino-terminal product is generated from the full-length protein through proteolytic cleavage. The protein is differentially regulated by E1A-induced phosphorylation. The full-length gene product represses transcription from the E4 promoter in the absence of E1A, while the 50-kDa form acts as a transcriptional activator in its presence. Alterna ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000301727
  • ENSP00000301727
  • ENSG00000167967

Symbol
  • E4F
  • E4F
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
molecular function
0.91
ligand (protein) perturbation
0.83
biological process
0.75
tissue sample
0.72
transcription factor binding site profile
0.71


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 44.88   (req: < 5)
Gene RIFs: 9   (req: <= 3)
Antibodies: 98   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 44.88   (req: >= 5)
Gene RIFs: 9   (req: > 3)
Antibodies: 98   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 20
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
No expression data found
Related Tools
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (100)
HIC2
Tbio
Family:  TF
Novelty:  0.1544738
p_int:  0.999999582
p_ni:  4.18e-7
Data Source:  BioPlex
ABT1
Tbio
Novelty:  0.05236553
p_int:  0.999860528
p_ni:  0.000139472
Data Source:  BioPlex
TRIM71
Tbio
Family:  Enzyme
Novelty:  0.01164618
p_int:  0.999793006
p_ni:  0.000206994
Score:  0.157
Data Source:  BioPlex,STRINGDB
HIST1H1A
Tbio
Novelty:  0.00123818
p_int:  0.999507971
p_ni:  0.000492028
p_wrong:  1e-9
Data Source:  BioPlex
UBE2O
Tbio
Novelty:  0.07084123
p_int:  0.998809565
p_ni:  0.001190435
Score:  0.159
Data Source:  BioPlex,STRINGDB
RPL36AL
Tbio
Novelty:  0.09336423
p_int:  0.996873772
p_ni:  0.003126228
Data Source:  BioPlex
RPL26L1
Tdark
Novelty:  0.75408617
p_int:  0.996094051
p_ni:  0.003905949
Data Source:  BioPlex
EFEMP1
Tbio
Novelty:  0.00574779
p_int:  0.995381606
p_ni:  0.000327412
p_wrong:  0.004290983
Data Source:  BioPlex
VWCE
Tbio
Novelty:  0.09328341
p_int:  0.98971811
p_ni:  0.000123913
p_wrong:  0.010157977
Data Source:  BioPlex
RPL26
Tbio
Novelty:  0.02077198
p_int:  0.987811947
p_ni:  0.012188053
Data Source:  BioPlex
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (23)
Find Similar Targets
Items per page:
10
1 – 10 of 10
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
NTNU_SB
Inferred from Sequence Alignment (ISA)
NTNU_SB
Traceable Author Statement (TAS)
ProtInc
Traceable Author Statement (TAS)
ProtInc
Traceable Author Statement (TAS)
ProtInc
Traceable Author Statement (TAS)
ProtInc
Inferred by Curator (IC)
NTNU_SB
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Disease Associations ()
No disease associations found
GWAS Traits (14)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
alkaline phosphatase measurement
2
2
1
6
91
BMI-adjusted hip circumference
2
5
7
75.9
neutrophil count
2
2
2
71.1
body height
2
2
2
70.9
waist-hip ratio
1
1
1
55.2
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
alkaline phosphatase measurement
1
6
91
BMI-adjusted hip circumference
7
75.9
neutrophil count
2
71.1
body height
2
70.9
waist-hip ratio
1
55.2
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (13)
1 – 5 of 13
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
E4F transcription factor 1
VGNC:8980
454356
Macaque
E4F transcription factor 1
695882
Mouse
MGI:109530
13560
Rat
RGD:1596731
681359
Horse
E4F transcription factor 1
VGNC:17390
100068273
Species
Name
OMA
EggNOG
Inparanoid
Chimp
E4F transcription factor 1
Macaque
E4F transcription factor 1
Mouse
Rat
Horse
E4F transcription factor 1
Publication Statistics
PubMed Score 44.88
PubMed score by year
PubTator Score 14.10
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title