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Tbio
E2F4
Transcription factor E2F4

Protein Summary
Description
Transcription activator that binds DNA cooperatively with DP proteins through the E2 recognition site, 5'-TTTC[CG]CGC-3' found in the promoter region of a number of genes whose products are involved in cell cycle regulation or in DNA replication. The DRTF1/E2F complex functions in the control of cell-cycle progression from G1 to S phase. E2F4 binds with high affinity to RBL1 and RBL2. In some instances can also bind RB1. Specifically required for multiciliate cell differentiation: together with MCIDAS and E2F5, binds and activate genes required for centriole biogenesis. The protein encoded by this gene is a member of the E2F family of transcription factors. The E2F family plays a crucial role in the control of cell cycle and action of tumor suppressor proteins and is also a target of the transforming proteins of small DNA tumor viruses. The E2F proteins contain several evolutionally conserved domains found in most members of the family. These domains include a DNA binding domain, a dim ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000379378
  • ENSP00000368686
  • ENSG00000205250

Symbol
  • E2F-4
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
virus perturbation
0.99
kinase perturbation
0.84
molecular function
0.84
biological process
0.81
transcription factor binding site profile
0.75


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 284.76   (req: < 5)
Gene RIFs: 47   (req: <= 3)
Antibodies: 401   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 284.76   (req: >= 5)
Gene RIFs: 47   (req: > 3)
Antibodies: 401   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 24
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
No expression data found
Related Tools
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (178)
TFDP2
Tbio
Family:  TF
Novelty:  0.14331363
p_int:  0.999999963
p_ni:  3.3e-8
p_wrong:  5e-9
Score:  0.997
Data Source:  BioPlex,Reactome,STRINGDB
POMC
Tbio
Novelty:  0.00002436
p_int:  0.999997002
p_ni:  0.000002953
p_wrong:  4.5e-8
Score:  0.451
Data Source:  BioPlex,STRINGDB
CCDC183
Tdark
Novelty:  1.55719016
p_int:  0.999995853
p_ni:  0.000004138
p_wrong:  1e-8
Score:  0.173
Data Source:  BioPlex,STRINGDB
TFDP3
Tbio
Family:  TF
Novelty:  0.00223003
p_int:  0.999984867
p_ni:  4.11e-7
p_wrong:  0.000014722
Score:  0.949
Data Source:  BioPlex,STRINGDB
GMNN
Tbio
Novelty:  0.00436572
p_int:  0.999800798
p_ni:  0.000014806
p_wrong:  0.000184396
Score:  0.444
Data Source:  BioPlex,STRINGDB
CDKN2AIP
Tbio
Novelty:  0.15331029
p_int:  0.999738299
p_ni:  0.00001476
p_wrong:  0.000246941
Data Source:  BioPlex
RBL1
Tbio
Novelty:  0.00228265
Score:  0.999
Data Source:  Reactome,STRINGDB
TFDP1
Tbio
Family:  TF
Novelty:  0.02026858
Score:  0.998
Data Source:  Reactome,STRINGDB
RBL2
Tbio
Novelty:  0.00121893
Score:  0.997
Data Source:  Reactome,STRINGDB
RB1
Tchem
Novelty:  0.00063798
Score:  0.995
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (34)
Cell Cycle (R-HSA-1640170)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 5 of 24
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Cell Cycle
Reactome
Cell Cycle, Mitotic
Reactome
Cyclin A:Cdk2-associated events at S phase entry
Reactome
Cyclin D associated events in G1
Reactome
Cyclin E associated events during G1/S transition
Name
Explore in Pharos
Explore in Source
Cell Cycle
Cell Cycle, Mitotic
Cyclin A:Cdk2-associated events at S phase entry
Cyclin D associated events in G1
Cyclin E associated events during G1/S transition
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (27)
Find Similar Targets
Items per page:
10
1 – 10 of 11
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
MGI
Inferred from Direct Assay (IDA)
NTNU_SB
Inferred from Physical Interaction (IPI)
UniProtKB
Inferred from Physical Interaction (IPI)
UniProtKB
Inferred from Mutant Phenotype (IMP)
UniProtKB
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Sequence Alignment (ISA)
NTNU_SB
Disease Associations ()
No disease associations found
GWAS Traits (14)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
mean corpuscular volume
1
4
4
96.2
mean reticulocyte volume
1
4
4
94.2
heel bone mineral density
3
3
6
93.1
high density lipoprotein cholesterol measurement
2
2
2
62.6
BMI-adjusted waist circumference
1
3
3
62.6
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
mean corpuscular volume
4
96.2
mean reticulocyte volume
4
94.2
heel bone mineral density
6
93.1
high density lipoprotein cholesterol measurement
2
62.6
BMI-adjusted waist circumference
3
62.6
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (11)
1 – 5 of 11
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
E2F transcription factor 4
VGNC:8979
454158
Macaque
E2F transcription factor 4
696864
Mouse
MGI:103012
104394
Rat
RGD:2322129
100360427
Dog
E2F transcription factor 4
VGNC:40166
611243
Species
Name
OMA
EggNOG
Inparanoid
Chimp
E2F transcription factor 4
Macaque
E2F transcription factor 4
Mouse
Rat
Dog
E2F transcription factor 4
Publication Statistics
PubMed Score 284.76
PubMed score by year
PubTator Score 162.96
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title