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Tbio
E2F3
Transcription factor E2F3

Protein Summary
Description
Transcription activator that binds DNA cooperatively with DP proteins through the E2 recognition site, 5'-TTTC[CG]CGC-3' found in the promoter region of a number of genes whose products are involved in cell cycle regulation or in DNA replication. The DRTF1/E2F complex functions in the control of cell-cycle progression from G1 to S phase. E2F3 binds specifically to RB1 in a cell-cycle dependent manner. Inhibits adipogenesis, probably through the repression of CEBPA binding to its target gene promoters (By similarity). This gene encodes a member of a small family of transcription factors that function through binding of DP interaction partner proteins. The encoded protein recognizes a specific sequence motif in DNA and interacts directly with the retinoblastoma protein (pRB) to regulate the expression of genes involved in the cell cycle. Altered copy number and activity of this gene have been observed in a number of human cancers. There are pseudogenes for this gene on chromosomes 2 and ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000346618
  • ENSP00000262904
  • ENSG00000112242
  • ENST00000535432
  • ENSP00000443418

Symbol
  • KIAA0075
  • E2F-3
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
transcription factor binding site profile
0.97
transcription factor
0.88
microRNA
0.86
disease perturbation
0.83
pathway
0.8


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 352.59   (req: < 5)
Gene RIFs: 82   (req: <= 3)
Antibodies: 320   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 352.59   (req: >= 5)
Gene RIFs: 82   (req: > 3)
Antibodies: 320   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 17
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (165)
TFDP2
Tbio
Family:  TF
Novelty:  0.14331363
p_int:  0.999999961
p_ni:  3.9e-8
Score:  0.952
Data Source:  BioPlex,Reactome,STRINGDB
TFDP3
Tbio
Family:  TF
Novelty:  0.00223003
p_int:  0.999999277
p_ni:  3e-9
p_wrong:  7.2e-7
Score:  0.872
Data Source:  BioPlex,STRINGDB
RB1
Tchem
Novelty:  0.00063798
Score:  0.995
Data Source:  Reactome,STRINGDB
CCNA2
Tchem
Novelty:  0.00049887
Score:  0.986
Data Source:  STRINGDB
TFDP1
Tbio
Family:  TF
Novelty:  0.02026858
Score:  0.985
Data Source:  Reactome,STRINGDB
RBL1
Tbio
Novelty:  0.00228265
Score:  0.983
Data Source:  STRINGDB
CDK4
Tclin
Family:  Kinase
Novelty:  0.00036742
Score:  0.978
Data Source:  STRINGDB
CDK6
Tclin
Family:  Kinase
Novelty:  0.00109319
Score:  0.978
Data Source:  STRINGDB
P42771
Tbio
Family:  Enzyme
Novelty:  0.00014147
Score:  0.976
Data Source:  STRINGDB
Q8N726
Tbio
Novelty:  0.00014147
Score:  0.976
Data Source:  STRINGDB
Nearest Tclin Targets (2)
Explore Nearest Tclin Targets
1 – 2 of 2
Pathways (56)
Assembly of the pre-replicative complex (R-HSA-68867)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 5 of 20
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Assembly of the pre-replicative complex
Reactome
CDC6 association with the ORC:origin complex
Reactome
Cell Cycle
Reactome
Cell Cycle, Mitotic
Reactome
Cellular Senescence
Name
Explore in Pharos
Explore in Source
Assembly of the pre-replicative complex
CDC6 association with the ORC:origin complex
Cell Cycle
Cell Cycle, Mitotic
Cellular Senescence
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (19)
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Items per page:
10
1 – 9 of 9
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
NTNU_SB
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Sequence Alignment (ISA)
NTNU_SB
Traceable Author Statement (TAS)
ProtInc
Inferred by Curator (IC)
NTNU_SB
Inferred from Electronic Annotation (IEA)
InterPro
Disease Associations (null)
No disease associations found
GWAS Traits (26)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
glomerular filtration rate
4
2
4
76
triglyceride measurement
7
3
7
75.1
waist-hip ratio
2
2
2
61.7
serum alanine aminotransferase measurement
2
1
1
6.2
59.1
body mass index
2
1
2
53.8
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
glomerular filtration rate
4
76
triglyceride measurement
7
75.1
waist-hip ratio
2
61.7
serum alanine aminotransferase measurement
1
6.2
59.1
body mass index
2
53.8
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (11)
1 – 5 of 11
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
E2F transcription factor 3
VGNC:11064
471865
Macaque
E2F transcription factor 3
713904
Mouse
MGI:1096340
13557
Rat
RGD:1561600
291105
Dog
E2F transcription factor 3
VGNC:40165
488239
Species
Name
OMA
EggNOG
Inparanoid
Chimp
E2F transcription factor 3
Macaque
E2F transcription factor 3
Mouse
Rat
Dog
E2F transcription factor 3
Publication Statistics
PubMed Score 352.59
PubMed score by year
PubTator Score 147.83
PubTator score by year
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Related Publications
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PMID
Year
Title