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Tbio
E2F2
Transcription factor E2F2

Protein Summary
Description
Transcription activator that binds DNA cooperatively with DP proteins through the E2 recognition site, 5'-TTTC[CG]CGC-3' found in the promoter region of a number of genes whose products are involved in cell cycle regulation or in DNA replication. The DRTF1/E2F complex functions in the control of cell-cycle progression from g1 to s phase. E2F2 binds specifically to RB1 in a cell-cycle dependent manner. The protein encoded by this gene is a member of the E2F family of transcription factors. The E2F family plays a crucial role in the control of cell cycle and action of tumor suppressor proteins and is also a target of the transforming proteins of small DNA tumor viruses. The E2F proteins contain several evolutionally conserved domains found in most members of the family. These domains include a DNA binding domain, a dimerization domain which determines interaction with the differentiation regulated transcription factor proteins (DP), a transactivation domain enriched in acidic amino acids ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000361729
  • ENSP00000355249
  • ENSG00000007968
  • ENST00000634683
  • ENSP00000489612
  • ENSG00000282899

Symbol
  • E2F-2
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
PubMedID
0.92
microRNA
0.8
transcription factor binding site profile
0.78
transcription factor perturbation
0.68
histone modification site profile
0.65


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 225.92   (req: < 5)
Gene RIFs: 44   (req: <= 3)
Antibodies: 322   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 225.92   (req: >= 5)
Gene RIFs: 44   (req: > 3)
Antibodies: 322   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 18
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (149)
TFDP2
Tbio
Family:  TF
Novelty:  0.14331363
p_int:  0.999999997
p_ni:  1e-9
p_wrong:  2e-9
Score:  0.946
Data Source:  BioPlex,Reactome,STRINGDB
RB1
Tchem
Novelty:  0.00063798
Score:  0.999
Data Source:  Reactome,STRINGDB
RBL1
Tbio
Novelty:  0.00228265
Score:  0.987
Data Source:  STRINGDB
TFDP1
Tbio
Family:  TF
Novelty:  0.02026858
Score:  0.985
Data Source:  Reactome,STRINGDB
CCNA2
Tchem
Novelty:  0.00049887
Score:  0.981
Data Source:  STRINGDB
CDK4
Tclin
Family:  Kinase
Novelty:  0.00036742
Score:  0.976
Data Source:  STRINGDB
CDK6
Tclin
Family:  Kinase
Novelty:  0.00109319
Score:  0.975
Data Source:  STRINGDB
CDK2
Tchem
Family:  Kinase
Novelty:  0.00032118
Score:  0.974
Data Source:  STRINGDB
CCND1
Tchem
Novelty:  0.0001186
Score:  0.97
Data Source:  STRINGDB
CCND2
Tbio
Novelty:  0.00157305
Score:  0.964
Data Source:  STRINGDB
Nearest Tclin Targets (2)
Explore Nearest Tclin Targets
1 – 2 of 2
Pathways (158)
Assembly of the pre-replicative complex (R-HSA-68867)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 5 of 14
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Assembly of the pre-replicative complex
Reactome
CDC6 association with the ORC:origin complex
Reactome
Cell Cycle
Reactome
Cell Cycle, Mitotic
Reactome
Cellular Senescence
Name
Explore in Pharos
Explore in Source
Assembly of the pre-replicative complex
CDC6 association with the ORC:origin complex
Cell Cycle
Cell Cycle, Mitotic
Cellular Senescence
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (20)
Find Similar Targets
Items per page:
10
1 – 10 of 10
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
NTNU_SB
Inferred from Physical Interaction (IPI)
UniProtKB
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Sequence Alignment (ISA)
NTNU_SB
Traceable Author Statement (TAS)
ProtInc
Non-traceable Author Statement (NAS)
ProtInc
Inferred by Curator (IC)
NTNU_SB
Inferred from Electronic Annotation (IEA)
InterPro
Disease Associations (null)
No disease associations found
GWAS Traits (44)
Items per page:
1 – 5 of 44
GWAS Trait
EFO ID
ENSG ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
red blood cell distribution width
4
2
4
92.5
red blood cell distribution width
4
2
4
92.5
serum gamma-glutamyl transferase measurement
2
2
2
89.4
serum gamma-glutamyl transferase measurement
2
2
2
89.4
mean corpuscular hemoglobin concentration
1
1
1
85.3
Items per page:
1 – 5 of 44
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
red blood cell distribution width
4
92.5
red blood cell distribution width
4
92.5
serum gamma-glutamyl transferase measurement
2
89.4
serum gamma-glutamyl transferase measurement
2
89.4
mean corpuscular hemoglobin concentration
1
85.3
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (9)
1 – 5 of 9
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
E2F transcription factor 2
VGNC:525
469153
Macaque
E2F transcription factor 2
710200
Mouse
MGI:1096341
242705
Rat
RGD:1593939
684111
Dog
E2F transcription factor 2
VGNC:40164
100855664
Species
Name
OMA
EggNOG
Inparanoid
Chimp
E2F transcription factor 2
Macaque
E2F transcription factor 2
Mouse
Rat
Dog
E2F transcription factor 2
Publication Statistics
PubMed Score 225.92
PubMed score by year
PubTator Score 97.80
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title