Tbio E2F1 Transcription factor E2F1

Protein Summary

Description

Transcription activator that binds DNA cooperatively with DP proteins through the E2 recognition site, 5'-TTTC[CG]CGC-3' found in the promoter region of a number of genes whose products are involved in cell cycle regulation or in DNA replication. The DRTF1/E2F complex functions in the control of cell-cycle progression from G1 to S phase. E2F1 binds preferentially RB1 in a cell-cycle dependent manner. It can mediate both cell proliferation and TP53/p53-dependent apoptosis. Blocks adipocyte differentiation by binding to specific promoters repressing CEBPA binding to its target gene promoters (PubMed:20176812). Positively regulates transcription of RRP1B (PubMed:20040599). The protein encoded by this gene is a member of the E2F family of transcription factors. The E2F family plays a crucial role in the control of cell cycle and action of tumor suppressor proteins and is also a target of the transforming proteins of small DNA tumor viruses. The E2F proteins contain several evolutionally conserved domains found in most members of the family. These domains include a DNA binding domain, a dimerization domain which determines interaction with the differentiation regulated transcription factor proteins (DP), a transactivation domain enriched in acidic amino acids, and a tumor suppressor protein association domain which is embedded within the transactivation domain. This protein and another 2 members, E2F2 and E2F3, have an additional cyclin binding domain. This protein binds preferentially to retinoblastoma protein pRB in a cell-cycle dependent manner. It can mediate both cell proliferation and p53-dependent/independent apoptosis. [provided by RefSeq, Jul 2008]

Uniprot Accession IDs

• Q01094
• Q13143
• Q92768
• E2F-1

Gene Name

• E2F1

Ensembl ID

• ENST00000343380
• ENSP00000345571
• ENSG00000101412

Symbol

• RBBP3
• RBP3
• E2F-1
• RBAP1
• RBBP3

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
biological process	0.99
hub protein	0.99
kinase	0.98
virus	0.98
pathway	0.93

Protein Classes

PANTHER Classes

Protein / Transcription Factor / Transcription Factor E2f1

Protein / Nucleic Acid Binding / Transcription Factor E2f1

DTO Classes

Protein / Nucleic Acid Binding / Transcription Factor E2f1

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 384.96   (req: < 5)

Gene RIFs: 705   (req: <= 3)

Antibodies: 1343   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 384.96   (req: >= 5)

Gene RIFs: 705   (req: > 3)

Antibodies: 1343   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 43

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0