You are using an outdated browser. Please upgrade your browser to improve your experience.

Tchem
DYRK1A
Dual specificity tyrosine-phosphorylation-regulated kinase 1A

Protein Summary
Description
Dual-specificity kinase which possesses both serine/threonine and tyrosine kinase activities. May play a role in a signaling pathway regulating nuclear functions of cell proliferation. Modulates alternative splicing by phosphorylating the splice factor SRSF6 (By similarity). Exhibits a substrate preference for proline at position P+1 and arginine at position P-3. Has pro-survival function and negatively regulates the apoptotic process. Promotes cell survival upon genotoxic stress through phosphorylation of SIRT1. This in turn inhibits TP53 activity and apoptosis (By similarity). This gene encodes a member of the Dual-specificity tyrosine phosphorylation-regulated kinase (DYRK) family. This member contains a nuclear targeting signal sequence, a protein kinase domain, a leucine zipper motif, and a highly conservative 13-consecutive-histidine repeat. It catalyzes its autophosphorylation on serine/threonine and tyrosine residues. It may play a significant role in a signaling pathway regula ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000338785
  • ENSP00000342690
  • ENSG00000157540
  • ENST00000339659
  • ENSP00000340373
  • ENST00000398956
  • ENSP00000381929
  • ENST00000398960
  • ENSP00000381932
  • ENST00000643624
  • ENSP00000493627
  • ENST00000644942
  • ENSP00000494544
  • ENST00000645424
  • ENSP00000494897
  • ENST00000646548
  • ENSP00000495908
  • ENST00000647188
  • ENSP00000494572
  • ENST00000647425
  • ENSP00000496748

Symbol
  • DYRK
  • MNB
  • MNBH
  • MNB
  • DYRK
  • HP86
  • MNBH
  • MRD7
  • DYRK1
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
kinase perturbation
1
molecular function
0.98
virus perturbation
0.95
disease perturbation
0.9
transcription factor binding site profile
0.87


Protein Classes
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 656.31   (req: < 5)
Gene RIFs: 107   (req: <= 3)
Antibodies: 392   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 656.31   (req: >= 5)
Gene RIFs: 107   (req: > 3)
Antibodies: 392   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 29
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 673
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0