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Tbio
DYNLRB2
Dynein light chain roadblock-type 2

Protein Summary
Description
Acts as one of several non-catalytic accessory components of the cytoplasmic dynein 1 complex that are thought to be involved in linking dynein to cargos and to adapter proteins that regulate dynein function. Cytoplasmic dynein 1 acts as a motor for the intracellular retrograde motility of vesicles and organelles along microtubules.
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000305904
  • ENSP00000302936
  • ENSG00000168589

Symbol
  • DNCL2B
  • DNLC2B
  • ROBLD2
  • DNCL2B
  • DNLC2B
  • ROBLD2
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
histone modification site profile
0.84
gene perturbation
0.76
tissue sample
0.74
transcription factor binding site profile
0.57
transcription factor
0.55


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 6.08   (req: < 5)
Gene RIFs: 4   (req: <= 3)
Antibodies: 91   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 6.08   (req: >= 5)
Gene RIFs: 4   (req: > 3)
Antibodies: 91   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 4
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (100)
WDR60
Tbio
Novelty:  0.13020561
Score:  0.979
Data Source:  STRINGDB
WDR34
Tbio
Novelty:  0.05515847
Score:  0.977
Data Source:  STRINGDB
TCTEX1D2
Tbio
Novelty:  0.15075459
Score:  0.975
Data Source:  STRINGDB
DYNC1I1
Tbio
Novelty:  0.12175372
Score:  0.972
Data Source:  STRINGDB
DYNLL2
Tbio
Novelty:  0.11209457
Score:  0.97
Data Source:  STRINGDB
DYNC2LI1
Tbio
Novelty:  0.05087433
Score:  0.97
Data Source:  STRINGDB
DYNLL1
Tbio
Novelty:  0.00397334
Score:  0.968
Data Source:  STRINGDB
DYNC1I2
Tbio
Novelty:  0.00228615
Score:  0.966
Data Source:  STRINGDB
DYNC2H1
Tbio
Novelty:  0.01306616
Score:  0.963
Data Source:  STRINGDB
TCTEX1D1
Tdark
Novelty:  1.09622578
Score:  0.95
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (6)
Cilium Assembly (R-HSA-5617833)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 3 of 3
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Cilium Assembly
Reactome
Intraflagellar transport
Reactome
Organelle biogenesis and maintenance
Name
Explore in Pharos
Explore in Source
Cilium Assembly
Intraflagellar transport
Organelle biogenesis and maintenance
Viral Interactions (0)
No viral interactions found
Disease Associations (null)
No disease associations found
GWAS Traits (11)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
serum gamma-glutamyl transferase measurement
4
4
4
3.2
87.9
4
2
0
1.1
80.6
balding measurement
1
2
2
71.6
interleukin 10 measurement
1
1
1
38.8
1
1
0
1.1
21.5
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
serum gamma-glutamyl transferase measurement
4
3.2
87.9
0
1.1
80.6
balding measurement
2
71.6
interleukin 10 measurement
1
38.8
0
1.1
21.5
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (13)
1 – 5 of 13
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
dynein light chain roadblock-type 2
VGNC:9387
454263
Macaque
dynein light chain roadblock-type 2
713503
Mouse
MGI:1922715
75465
Rat
RGD:1306930
361415
Dog
dynein light chain roadblock-type 2
VGNC:40153
479636
Species
Name
OMA
EggNOG
Inparanoid
Chimp
dynein light chain roadblock-type 2
Macaque
dynein light chain roadblock-type 2
Mouse
Rat
Dog
dynein light chain roadblock-type 2
Publication Statistics
PubMed Score 6.08
PubMed score by year
PubTator Score 2.85
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title