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Tbio
DYNLRB1
Dynein light chain roadblock-type 1

Protein Summary
Description
Acts as one of several non-catalytic accessory components of the cytoplasmic dynein 1 complex that are thought to be involved in linking dynein to cargos and to adapter proteins that regulate dynein function. Cytoplasmic dynein 1 acts as a motor for the intracellular retrograde motility of vesicles and organelles along microtubules. This gene is a member of the roadblock dynein light chain family. The encoded cytoplasmic protein is capable of binding intermediate chain proteins, interacts with transforming growth factor-beta, and has been implicated in the regulation of actin modulating proteins. Upregulation of this gene has been associated with hepatocellular carcinomas, suggesting that this gene may be involved in tumor progression. Alternative splicing results in multiple transcript variants. Pseudogenes of this gene have been defined on chromosomes 12 and 18. [provided by RefSeq, Aug 2013]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000300469
  • ENSP00000300469
  • ENSG00000125971
  • ENST00000357156
  • ENSP00000349679

Symbol
  • BITH
  • DNCL2A
  • DNLC2A
  • ROBLD1
  • BLP
  • BITH
  • DNCL2A
  • DNLC2A
  • ROBLD1
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
kinase perturbation
1
disease perturbation
0.99
interacting protein
0.91
histone modification site profile
0.88
tissue
0.77


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 77.84   (req: < 5)
Gene RIFs: 10   (req: <= 3)
Antibodies: 64   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 77.84   (req: >= 5)
Gene RIFs: 10   (req: > 3)
Antibodies: 64   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 5
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
No expression data found
Related Tools
Target Illumination GWAS Analytics (TIGA)
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TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (126)
CHCHD4
Tbio
Novelty:  0.01204944
p_int:  0.917741387
p_ni:  0.082258613
Data Source:  BioPlex
DYNC1H1
Tbio
Novelty:  0.0098543
Score:  0.997
Data Source:  STRINGDB
DYNLT1
Tbio
Novelty:  0.00336045
Score:  0.989
Data Source:  STRINGDB
DYNLL1
Tbio
Novelty:  0.00397334
Score:  0.984
Data Source:  STRINGDB
DYNC1I1
Tbio
Novelty:  0.12175372
Score:  0.984
Data Source:  STRINGDB
DYNC1LI2
Tbio
Novelty:  0.17381295
Score:  0.981
Data Source:  STRINGDB
WDR34
Tbio
Novelty:  0.05515847
Score:  0.975
Data Source:  STRINGDB
DYNC1I2
Tbio
Novelty:  0.00228615
Score:  0.974
Data Source:  STRINGDB
WDR60
Tbio
Novelty:  0.13020561
Score:  0.973
Data Source:  STRINGDB
TCTEX1D2
Tbio
Novelty:  0.15075459
Score:  0.971
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (7)
Cilium Assembly (R-HSA-5617833)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 3 of 3
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Cilium Assembly
Reactome
Intraflagellar transport
Reactome
Organelle biogenesis and maintenance
Name
Explore in Pharos
Explore in Source
Cilium Assembly
Intraflagellar transport
Organelle biogenesis and maintenance
Viral Interactions (0)
No viral interactions found
Disease Associations ()
No disease associations found
GWAS Traits (19)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
appendicular lean mass
3
4
7
96.7
glomerular filtration rate
3
3
3
94.1
sex hormone-binding globulin measurement
4
2
4
87.7
hair color
1
1
0
1.5
85.8
creatinine measurement
2
2
2
83.2
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
appendicular lean mass
7
96.7
glomerular filtration rate
3
94.1
sex hormone-binding globulin measurement
4
87.7
hair color
0
1.5
85.8
creatinine measurement
2
83.2
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (11)
1 – 5 of 11
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
dynein light chain roadblock-type 1
VGNC:14128
458192
Macaque
dynein light chain roadblock-type 1
100428465
Mouse
MGI:1914318
67068
Rat
RGD:619910
170714
Dog
dynein light chain roadblock-type 1
VGNC:40152
477200
Species
Name
OMA
EggNOG
Inparanoid
Chimp
dynein light chain roadblock-type 1
Macaque
dynein light chain roadblock-type 1
Mouse
Rat
Dog
dynein light chain roadblock-type 1
Publication Statistics
PubMed Score 77.84
PubMed score by year
PubTator Score 50.68
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title