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Tbio
DYNLL2
Dynein light chain 2, cytoplasmic

Protein Summary
Description
Acts as one of several non-catalytic accessory components of the cytoplasmic dynein 1 complex that are thought to be involved in linking dynein to cargos and to adapter proteins that regulate dynein function. Cytoplasmic dynein 1 acts as a motor for the intracellular retrograde motility of vesicles and organelles along microtubules. May play a role in changing or maintaining the spatial distribution of cytoskeletal structures (By similarity).
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000579991
  • ENSP00000477310
  • ENSG00000264364

Symbol
  • DLC2
  • Dlc2
  • DNCL1B
  • RSPH22
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
small molecule perturbation
0.93
disease perturbation
0.83
protein complex
0.78
virus perturbation
0.76
cell type or tissue
0.73


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 6.87   (req: < 5)
Gene RIFs: 2   (req: <= 3)
Antibodies: 137   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 6.87   (req: >= 5)
Gene RIFs: 2   (req: > 3)
Antibodies: 137   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 11
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
No expression data found
Related Tools
Target Illumination GWAS Analytics (TIGA)
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TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (366)
DNAL4
Tbio
Novelty:  0.15546154
p_int:  0.999986543
p_ni:  0.000013457
p_wrong:  1e-9
Score:  0.615
Data Source:  BioPlex,STRINGDB
LRFN4
Tbio
Novelty:  0.12511571
p_int:  0.997454968
p_ni:  0.002545032
Score:  0.217
Data Source:  BioPlex,STRINGDB
DYNLL1
Tbio
Novelty:  0.00397334
Score:  0.997
Data Source:  Reactome,STRINGDB
DYNC1H1
Tbio
Novelty:  0.0098543
Score:  0.992
Data Source:  Reactome,STRINGDB
DYNC1I1
Tbio
Novelty:  0.12175372
Score:  0.991
Data Source:  Reactome,STRINGDB
DYNC1I2
Tbio
Novelty:  0.00228615
Score:  0.99
Data Source:  Reactome,STRINGDB
WDR34
Tbio
Novelty:  0.05515847
Score:  0.985
Data Source:  STRINGDB
TCTE3
Tdark
Novelty:  0.15747856
Score:  0.976
Data Source:  STRINGDB
WDR60
Tbio
Novelty:  0.13020561
Score:  0.974
Data Source:  STRINGDB
DYNLRB2
Tbio
Novelty:  0.1714161
Score:  0.97
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (47)
Activation of BH3-only proteins (R-HSA-114452)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 5 of 43
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Activation of BH3-only proteins
Reactome
Activation of BMF and translocation to mitochondria
Reactome
Adaptive Immune System
Reactome
Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal
Reactome
Amplification of signal from the kinetochores
Name
Explore in Pharos
Explore in Source
Activation of BH3-only proteins
Activation of BMF and translocation to mitochondria
Adaptive Immune System
Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal
Amplification of signal from the kinetochores
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (25)
Find Similar Targets
Items per page:
10
1 – 6 of 6
GO Term
Evidence
Assigned by
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Inferred from Electronic Annotation (IEA)
Ensembl
Inferred from Electronic Annotation (IEA)
Ensembl
Inferred from Electronic Annotation (IEA)
Ensembl
Disease Associations ()
No disease associations found
GWAS Traits (2)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
self reported educational attainment
1
1
1
11.2
body mass index
2
1
2
7.7
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
self reported educational attainment
1
11.2
body mass index
2
7.7
IDG Resources
No IDG generated resources found
Orthologs (13)
1 – 5 of 13
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
dynein light chain LC8-type 2
VGNC:12094
748058
Mouse
MGI:1915347
68097
Rat
RGD:619860
140734
Dog
dynein light chain LC8-type 2
VGNC:40151
480569
Horse
dynein light chain LC8-type 2
VGNC:17373
100070859
Species
Name
OMA
EggNOG
Inparanoid
Chimp
dynein light chain LC8-type 2
Mouse
Rat
Dog
dynein light chain LC8-type 2
Horse
dynein light chain LC8-type 2
Publication Statistics
PubMed Score 6.87
PubMed score by year
PubTator Score 13.54
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title