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Tbio
DYNLL1
Dynein light chain 1, cytoplasmic

Protein Summary
Description
Acts as one of several non-catalytic accessory components of the cytoplasmic dynein 1 complex that are thought to be involved in linking dynein to cargos and to adapter proteins that regulate dynein function. Cytoplasmic dynein 1 acts as a motor for the intracellular retrograde motility of vesicles and organelles along microtubules. May play a role in changing or maintaining the spatial distribution of cytoskeletal structures. Binds and inhibits the catalytic activity of neuronal nitric oxide synthase. Promotes transactivation functions of ESR1 and plays a role in the nuclear localization of ESR1. Regulates apoptotic activities of BCL2L11 by sequestering it to microtubules. Upon apoptotic stimuli the BCL2L11-DYNLL1 complex dissociates from cytoplasmic dynein and translocates to mitochondria and sequesters BCL2 thus neutralizing its antiapoptotic activity. Cytoplasmic dyneins are large enzyme complexes with a molecular mass of about 1,200 kD. They contain two force-producing heads forme ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000242577
  • ENSP00000242577
  • ENSG00000088986
  • ENST00000392508
  • ENSP00000376296
  • ENST00000392509
  • ENSP00000376297
  • ENST00000548342
  • ENSP00000447907
  • ENST00000549989
  • ENSP00000446614

Symbol
  • DLC1
  • DNCL1
  • DNCLC1
  • HDLC1
  • LC8
  • PIN
  • DLC1
  • DLC8
  • LC8a
  • DNCL1
  • hdlc1
  • DNCLC1
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
disease perturbation
1
interacting protein
1
kinase perturbation
0.99
hub protein
0.98
biological process
0.92


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 405.84   (req: < 5)
Gene RIFs: 44   (req: <= 3)
Antibodies: 264   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 405.84   (req: >= 5)
Gene RIFs: 44   (req: > 3)
Antibodies: 264   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 28
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0