Tbio DYNC2LI1 Cytoplasmic dynein 2 light intermediate chain 1

Protein Summary

Description

Required for correct intraflagellar transport (IFT), the bi-directional movement of particles required for the assembly, maintenance and functioning of primary cilia. Involved in the regulation of ciliary length. This gene encodes a protein that is a component of the dynein-2 microtubule motor protein complex that plays a role in the retrograde transport of cargo in primary cilia via the intraflagellar transport system. This gene is ubiquitously expressed and its protein, which localizes to the axoneme and Golgi apparatus, interacts directly with the cytoplasmic dynein 2 heavy chain 1 protein to form part of the multi-protein dynein-2 complex. Mutations in this gene produce defects in the dynein-2 complex which result in several types of ciliopathy including short-rib thoracic dysplasia 15 with polydactyly (SRTD15). Alternative splicing results in multiple transcript variants encoding distinct isoforms. [provided by RefSeq, Feb 2017]

Uniprot Accession IDs

• Q8TCX1
• A8MVJ5
• Q53F57
• Q6PDB2
• Q8IWA3
• Q96B03
• Q96J00
• Q9Y370
• Q9Y3S9
• Dynein 2 light intermediate chain

Gene Name

• DYNC2LI1

Ensembl ID

• ENST00000260605
• ENSP00000260605
• ENSG00000138036
• ENST00000398823
• ENSP00000381804
• ENST00000406852
• ENSP00000385738
• ENST00000605786
• ENSP00000474032

Symbol

• D2LIC
• LIC3
• LIC3
• D2LIC
• CGI-60

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
histone modification site profile	0.8
cellular component	0.77
tissue sample	0.72
kinase perturbation	0.54
transcription factor perturbation	0.54

Protein Classes

PANTHER Classes

Protein / Cytoskeletal Protein / Microtubule Family Cytoskeletal Protein / Cytoplasmic Dynein 2 Light Intermediate Chain 1

DTO Classes

Protein / Cellular Structure / Microtubule Family Cytoskeletal Protein / Cytoplasmic Dynein 2 Light Intermediate Chain 1

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 27.7   (req: < 5)

Gene RIFs: 6   (req: <= 3)

Antibodies: 80   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 27.7   (req: >= 5)

Gene RIFs: 6   (req: > 3)

Antibodies: 80   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 6

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0