You are using an outdated browser. Please upgrade your browser to improve your experience.

Tbio
DYNC2LI1
Cytoplasmic dynein 2 light intermediate chain 1

Protein Summary
Description
Required for correct intraflagellar transport (IFT), the bi-directional movement of particles required for the assembly, maintenance and functioning of primary cilia. Involved in the regulation of ciliary length. This gene encodes a protein that is a component of the dynein-2 microtubule motor protein complex that plays a role in the retrograde transport of cargo in primary cilia via the intraflagellar transport system. This gene is ubiquitously expressed and its protein, which localizes to the axoneme and Golgi apparatus, interacts directly with the cytoplasmic dynein 2 heavy chain 1 protein to form part of the multi-protein dynein-2 complex. Mutations in this gene produce defects in the dynein-2 complex which result in several types of ciliopathy including short-rib thoracic dysplasia 15 with polydactyly (SRTD15). Alternative splicing results in multiple transcript variants encoding distinct isoforms. [provided by RefSeq, Feb 2017]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000260605
  • ENSP00000260605
  • ENSG00000138036
  • ENST00000398823
  • ENSP00000381804
  • ENST00000406852
  • ENSP00000385738
  • ENST00000605786
  • ENSP00000474032

Symbol
  • D2LIC
  • LIC3
  • LIC3
  • D2LIC
  • CGI-60
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
histone modification site profile
0.8
cellular component
0.77
tissue sample
0.72
kinase perturbation
0.54
transcription factor perturbation
0.54


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 27.7   (req: < 5)
Gene RIFs: 3   (req: <= 3)
Antibodies: 80   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 27.7   (req: >= 5)
Gene RIFs: 3   (req: > 3)
Antibodies: 80   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 6
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (126)
DYNC2H1
Tbio
Novelty:  0.01306616
p_int:  0.999999995
p_ni:  5e-9
Score:  0.997
Data Source:  BioPlex,STRINGDB
PCYOX1
Tbio
Family:  Enzyme
Novelty:  0.18505748
p_int:  0.998440629
p_ni:  0.001559371
Score:  0.206
Data Source:  BioPlex,STRINGDB
EPHA1
Tchem
Family:  Kinase
Novelty:  0.00136672
p_int:  0.962529895
p_ni:  0.037470081
p_wrong:  2.4e-8
Data Source:  BioPlex
TTC3
Tbio
Family:  Enzyme
Novelty:  0.03120223
p_int:  0.948369713
p_ni:  0.000020943
p_wrong:  0.051609344
Score:  0.517
Data Source:  BioPlex,STRINGDB
CLEC2D
Tbio
Novelty:  0.02501194
p_int:  0.92542686
p_ni:  0.074573138
p_wrong:  2e-9
Data Source:  BioPlex
TTC19
Tbio
Novelty:  0.08251578
p_int:  0.856758837
p_ni:  0.143241163
Score:  0.216
Data Source:  BioPlex,STRINGDB
LAMP2
Tbio
Novelty:  0.00168009
p_int:  0.751837223
p_ni:  0.248162777
Data Source:  BioPlex
IFT140
Tbio
Novelty:  0.02872897
Score:  0.983
Data Source:  STRINGDB
WDR19
Tbio
Novelty:  0.037197
Score:  0.981
Data Source:  STRINGDB
IFT57
Tbio
Novelty:  0.03373199
Score:  0.981
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (7)
Cilium Assembly (R-HSA-5617833)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 3 of 3
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Cilium Assembly
Reactome
Intraflagellar transport
Reactome
Organelle biogenesis and maintenance
Name
Explore in Pharos
Explore in Source
Cilium Assembly
Intraflagellar transport
Organelle biogenesis and maintenance
Viral Interactions (0)
No viral interactions found
Disease Associations (null)
No disease associations found
GWAS Traits (48)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
low density lipoprotein cholesterol measurement
44
20
57
3.5
99.8
total cholesterol measurement
23
20
35
3.6
99.4
4
2
0
1.8
99
phytosterol measurement
1
2
0
13
97.8
lipid measurement
12
4
11
6
97.3
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
low density lipoprotein cholesterol measurement
57
3.5
99.8
total cholesterol measurement
35
3.6
99.4
0
1.8
99
phytosterol measurement
0
13
97.8
lipid measurement
11
6
97.3
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (15)
1 – 5 of 15
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
dynein cytoplasmic 2 light intermediate chain 1
VGNC:483
459189
Macaque
dynein cytoplasmic 2 light intermediate chain 1
716480
Mouse
MGI:1913996
213575
Rat
RGD:1310286
298767
Dog
dynein cytoplasmic 2 light intermediate chain 1
VGNC:40149
474570
Species
Name
OMA
EggNOG
Inparanoid
Chimp
dynein cytoplasmic 2 light intermediate chain 1
Macaque
dynein cytoplasmic 2 light intermediate chain 1
Mouse
Rat
Dog
dynein cytoplasmic 2 light intermediate chain 1
Publication Statistics
PubMed Score 27.70
PubMed score by year
PubTator Score 6.55
PubTator score by year
loading...
Related Publications
Items per page:
0 of 0
PMID
Year
Title