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Tbio
DYNC2H1
Cytoplasmic dynein 2 heavy chain 1

Protein Summary
Description
May function as a motor for intraflagellar retrograde transport. Functions in cilia biogenesis. May play a role in transport between endoplasmic reticulum and Golgi or organization of the Golgi in cells (By similarity). This gene encodes a large cytoplasmic dynein protein that is involved in retrograde transport in the cilium and has a role in intraflagellar transport, a process required for ciliary/flagellar assembly. Mutations in this gene cause a heterogeneous spectrum of conditions related to altered primary cilium function and often involve polydactyly, abnormal skeletogenesis, and polycystic kidneys. Alternative splicing results in multiple transcript variants encoding distinct proteins. [provided by RefSeq, Jan 2010]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000334267
  • ENSP00000334021
  • ENSG00000187240
  • ENST00000375735
  • ENSP00000364887
  • ENST00000398093
  • ENSP00000381167
  • ENST00000649997
  • ENSP00000496872
  • ENST00000650373
  • ENSP00000497174

Symbol
  • DHC1B
  • DHC2
  • DNCH2
  • DYH1B
  • KIAA1997
  • ATD3
  • DHC2
  • DHC1b
  • DNCH2
  • DYH1B
  • SRTD3
  • SRPS2B
  • hdhc11
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
protein domain
1
molecular function
0.93
cellular component
0.84
histone modification site profile
0.79
virus perturbation
0.72


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 97.11   (req: < 5)
Gene RIFs: 18   (req: <= 3)
Antibodies: 44   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 97.11   (req: >= 5)
Gene RIFs: 18   (req: > 3)
Antibodies: 44   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 12
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0