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Tbio
DYNC1LI2
Cytoplasmic dynein 1 light intermediate chain 2

Protein Summary
Description
Acts as one of several non-catalytic accessory components of the cytoplasmic dynein 1 complex that are thought to be involved in linking dynein to cargos and to adapter proteins that regulate dynein function. Cytoplasmic dynein 1 acts as a motor for the intracellular retrograde motility of vesicles and organelles along microtubules. May play a role in binding dynein to membranous organelles or chromosomes. Cytoplasmic dynein is a microtubule-associated motor protein (Hughes et al., 1995 [PubMed 7738094]). See DYNC1H1 (MIM 600112) for general information about dyneins.[supplied by OMIM, Mar 2008]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000258198
  • ENSP00000258198
  • ENSG00000135720
  • ENST00000443351
  • ENSP00000394289

Symbol
  • DNCLI2
  • LIC2
  • LIC2
  • DNCLI2
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
interacting protein
1
virus perturbation
0.99
molecular function
0.91
transcription factor perturbation
0.74
microRNA
0.69


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 6.77   (req: < 5)
Gene RIFs: 7   (req: <= 3)
Antibodies: 108   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 6.77   (req: >= 5)
Gene RIFs: 7   (req: > 3)
Antibodies: 108   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 10
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
No expression data found
Related Tools
Target Illumination GWAS Analytics (TIGA)
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TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (328)
DYNC1I2
Tbio
Novelty:  0.00228615
p_int:  0.999498983
p_ni:  0.000501017
Score:  0.997
Data Source:  BioPlex,Reactome,STRINGDB
DYNC1I1
Tbio
Novelty:  0.12175372
p_int:  0.999435532
p_ni:  0.000564468
Score:  0.996
Data Source:  BioPlex,Reactome,STRINGDB
RASEF
Tbio
Novelty:  0.08877022
p_int:  0.998383363
p_ni:  0.001616637
Data Source:  BioPlex
CYP2J2
Tchem
Novelty:  0.00534181
p_int:  0.929514289
p_ni:  0.070485711
Data Source:  BioPlex
C2CD2
Tdark
Novelty:  0.34079266
p_int:  0.893740887
p_ni:  0.106259113
Score:  0.323
Data Source:  BioPlex,STRINGDB
CSTL1
Tbio
Novelty:  0.13370814
p_int:  0.798301201
p_ni:  0.201698799
Data Source:  BioPlex
PCBP4
Tbio
Novelty:  0.03763262
p_int:  0.751325815
p_ni:  0.248674185
Score:  0.282
Data Source:  BioPlex,STRINGDB
DYNC1H1
Tbio
Novelty:  0.0098543
Score:  0.999
Data Source:  Reactome,STRINGDB
DYNC1LI1
Tbio
Novelty:  0.02164556
Score:  0.993
Data Source:  Reactome,STRINGDB
DCTN2
Tbio
Novelty:  0.01045432
Score:  0.992
Data Source:  Reactome,STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (43)
Adaptive Immune System (R-HSA-1280218)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 5 of 33
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Adaptive Immune System
Reactome
Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal
Reactome
Amplification of signal from the kinetochores
Reactome
Asparagine N-linked glycosylation
Reactome
COPI-independent Golgi-to-ER retrograde traffic
Name
Explore in Pharos
Explore in Source
Adaptive Immune System
Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal
Amplification of signal from the kinetochores
Asparagine N-linked glycosylation
COPI-independent Golgi-to-ER retrograde traffic
Viral Interactions (0)
No viral interactions found
Disease Associations ()
No disease associations found
GWAS Traits (2)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
self reported educational attainment
1
1
1
14.2
C-reactive protein measurement
1
1
1
3.3
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
self reported educational attainment
1
14.2
C-reactive protein measurement
1
3.3
IDG Resources
No IDG generated resources found
Orthologs (14)
1 – 5 of 14
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
dynein cytoplasmic 1 light intermediate chain 2
VGNC:13701
740409
Macaque
dynein cytoplasmic 1 light intermediate chain 2
694204
Mouse
MGI:107738
234663
Rat
RGD:621130
81655
Dog
dynein cytoplasmic 1 light intermediate chain 2
VGNC:40147
479693
Species
Name
OMA
EggNOG
Inparanoid
Chimp
dynein cytoplasmic 1 light intermediate chain 2
Macaque
dynein cytoplasmic 1 light intermediate chain 2
Mouse
Rat
Dog
dynein cytoplasmic 1 light intermediate chain 2
Publication Statistics
PubMed Score 6.77
PubMed score by year
PubTator Score 9.31
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title