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Tbio
DYNC1LI1
Cytoplasmic dynein 1 light intermediate chain 1

Protein Summary
Description
Acts as one of several non-catalytic accessory components of the cytoplasmic dynein 1 complex that are thought to be involved in linking dynein to cargos and to adapter proteins that regulate dynein function. Cytoplasmic dynein 1 acts as a motor for the intracellular retrograde motility of vesicles and organelles along microtubules. May play a role in binding dynein to membranous organelles or chromosomes. Probably involved in the microtubule-dependent transport of pericentrin. Is required for progress through the spindle assembly checkpoint. The phosphorylated form appears to be involved in the selective removal of MAD1L1 and MAD1L2 but not BUB1B from kinetochores. The protein encoded by this gene belongs to light intermediate subunit family, whose members are components of the multiprotein cytoplasmic dynein complex, which is involved in intracellular trafficking and chromosome segregation during mitosis. The protein plays a role in moving the spindle assembly checkpoint (SAC) from k ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000273130
  • ENSP00000273130
  • ENSG00000144635

Symbol
  • DNCLI1
  • LIC1
  • DLC-A
  • DNCLI1
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
drug perturbation
1
molecular function
0.96
histone modification site profile
0.86
ligand (protein) perturbation
0.83
cellular component
0.82


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 53.27   (req: < 5)
Gene RIFs: 8   (req: <= 3)
Antibodies: 173   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 53.27   (req: >= 5)
Gene RIFs: 8   (req: > 3)
Antibodies: 173   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 14
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (334)
DYNC1I2
Tbio
Novelty:  0.00228615
p_int:  0.999999154
p_ni:  8.46e-7
Score:  0.996
Data Source:  BioPlex,Reactome,STRINGDB
TRPT1
Tdark
Family:  Enzyme
Novelty:  0.33062895
p_int:  0.999873296
p_ni:  0.000126704
Score:  0.269
Data Source:  BioPlex,STRINGDB
DYNC1I1
Tbio
Novelty:  0.12175372
p_int:  0.993888848
p_ni:  0.006111152
Score:  0.994
Data Source:  BioPlex,Reactome,STRINGDB
DYNC1H1
Tbio
Novelty:  0.0098543
p_int:  0.993061133
p_ni:  0.006938867
Score:  0.999
Data Source:  BioPlex,Reactome,STRINGDB
C2CD2
Tdark
Novelty:  0.34079266
p_int:  0.882043633
p_ni:  0.117956367
Score:  0.345
Data Source:  BioPlex,STRINGDB
RASEF
Tbio
Novelty:  0.08877022
p_int:  0.795200614
p_ni:  0.204799386
Data Source:  BioPlex
NFS1
Tbio
Family:  Enzyme
Novelty:  0.01274706
p_int:  0.759783621
p_ni:  0.240216378
p_wrong:  1e-9
Data Source:  BioPlex
DYNLT3
Tbio
Novelty:  0.10969629
Score:  0.994
Data Source:  STRINGDB
DYNC1LI2
Tbio
Novelty:  0.17381295
Score:  0.993
Data Source:  Reactome,STRINGDB
DYNLT1
Tbio
Novelty:  0.00336045
Score:  0.988
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (41)
Adaptive Immune System (R-HSA-1280218)

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Find Similar Targets
Items per page:
1 – 5 of 35
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Adaptive Immune System
Reactome
Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal
Reactome
Amplification of signal from the kinetochores
Reactome
Asparagine N-linked glycosylation
Reactome
COPI-independent Golgi-to-ER retrograde traffic
Name
Explore in Pharos
Explore in Source
Adaptive Immune System
Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal
Amplification of signal from the kinetochores
Asparagine N-linked glycosylation
COPI-independent Golgi-to-ER retrograde traffic
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (25)
Find Similar Targets
Items per page:
10
1 – 5 of 5
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
FlyBase
Inferred from Physical Interaction (IPI)
FlyBase
Inferred from High Throughput Direct Assay (HDA)
UniProtKB
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Inferred from Electronic Annotation (IEA)
InterPro
Disease Associations (null)
No disease associations found
GWAS Traits (6)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
low density lipoprotein cholesterol measurement
6
6
6
94.5
total cholesterol measurement
5
4
5
92.4
apolipoprotein B measurement
2
2
2
83.4
blood protein measurement
7
1
7
74
lymphocyte count
2
1
2
36
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
low density lipoprotein cholesterol measurement
6
94.5
total cholesterol measurement
5
92.4
apolipoprotein B measurement
2
83.4
blood protein measurement
7
74
lymphocyte count
2
36
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (12)
1 – 5 of 12
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
dynein cytoplasmic 1 light intermediate chain 1
VGNC:8834
460251
Mouse
MGI:2135610
235661
Rat
RGD:71072
252902
Dog
dynein cytoplasmic 1 light intermediate chain 1
VGNC:40146
477038
Horse
dynein cytoplasmic 1 light intermediate chain 1
VGNC:17369
100056767
Species
Name
OMA
EggNOG
Inparanoid
Chimp
dynein cytoplasmic 1 light intermediate chain 1
Mouse
Rat
Dog
dynein cytoplasmic 1 light intermediate chain 1
Horse
dynein cytoplasmic 1 light intermediate chain 1
Publication Statistics
PubMed Score 53.27
PubMed score by year
PubTator Score 34.59
PubTator score by year
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Related Publications
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0 of 0
PMID
Year
Title