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Tbio
DYNC1I2
Cytoplasmic dynein 1 intermediate chain 2

Protein Summary
Description
Acts as one of several non-catalytic accessory components of the cytoplasmic dynein 1 complex that are thought to be involved in linking dynein to cargos and to adapter proteins that regulate dynein function. Cytoplasmic dynein 1 acts as a motor for the intracellular retrograde motility of vesicles and organelles along microtubules. The intermediate chains mediate the binding of dynein to dynactin via its 150 kDa component (p150-glued) DCNT1. Involved in membrane-transport, such as Golgi apparatus, late endosomes and lysosomes. This gene encodes a member of the dynein intermediate chain family. The encoded protein is a non-catalytic component of the cytoplasmic dynein 1 complex, which acts as a retrograde microtubule motor to transport organelles and vesicles. A pseudogene of this gene is located on chromosome 10. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Nov 2012]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000340296
  • ENSP00000339430
  • ENSG00000077380
  • ENST00000397119
  • ENSP00000380308
  • ENST00000409197
  • ENSP00000386397
  • ENST00000409317
  • ENSP00000386591
  • ENST00000409453
  • ENSP00000386886
  • ENST00000409773
  • ENSP00000386415
  • ENST00000410079
  • ENSP00000386522
  • ENST00000508530
  • ENSP00000423339

Symbol
  • DNCI2
  • DNCIC2
  • IC2
  • DIC74
  • DNCI2
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
interacting protein
1
co-expressed gene
0.98
virus perturbation
0.94
transcription factor binding site profile
0.85
transcription factor perturbation
0.8


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 444.96   (req: < 5)
Gene RIFs: 3   (req: <= 3)
Antibodies: 128   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 444.96   (req: >= 5)
Gene RIFs: 3   (req: > 3)
Antibodies: 128   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 10
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
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TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (462)
DYNC1LI1
Tbio
Novelty:  0.02164556
p_int:  0.999999154
p_ni:  8.46e-7
Score:  0.996
Data Source:  BioPlex,Reactome,STRINGDB
PAPSS1
Tbio
Family:  Enzyme
Novelty:  0.01784751
p_int:  0.999965275
p_ni:  0.000034725
Score:  0.737
Data Source:  BioPlex,STRINGDB
ITK
Tclin
Family:  Kinase
Novelty:  0.00054195
p_int:  0.999732299
p_ni:  0.000267701
Score:  0.34
Data Source:  BioPlex,STRINGDB
DYNC1LI2
Tbio
Novelty:  0.17381295
p_int:  0.999498983
p_ni:  0.000501017
Score:  0.997
Data Source:  BioPlex,Reactome,STRINGDB
DYNC1H1
Tbio
Novelty:  0.0098543
p_int:  0.998307046
p_ni:  0.001692954
Score:  0.998
Data Source:  BioPlex,Reactome,STRINGDB
GNL1
Tbio
Novelty:  0.02864525
p_int:  0.920548535
p_ni:  0.079430204
p_wrong:  0.000021261
Score:  0.71
Data Source:  BioPlex,STRINGDB
DYNC1I1
Tbio
Novelty:  0.12175372
p_int:  0.904373514
p_ni:  0.095626486
Score:  0.987
Data Source:  BioPlex,Reactome,STRINGDB
DCTN1
Tbio
Novelty:  0.00494896
Score:  0.996
Data Source:  Reactome,STRINGDB
DCTN2
Tbio
Novelty:  0.01045432
Score:  0.993
Data Source:  Reactome,STRINGDB
DYNLL1
Tbio
Novelty:  0.00397334
Score:  0.992
Data Source:  Reactome,STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (51)
AURKA Activation by TPX2 (R-HSA-8854518)

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Find Similar Targets
Items per page:
1 – 5 of 45
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
AURKA Activation by TPX2
Reactome
Adaptive Immune System
Reactome
Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal
Reactome
Amplification of signal from the kinetochores
Reactome
Anchoring of the basal body to the plasma membrane
Name
Explore in Pharos
Explore in Source
AURKA Activation by TPX2
Adaptive Immune System
Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal
Amplification of signal from the kinetochores
Anchoring of the basal body to the plasma membrane
Viral Interactions (0)
No viral interactions found
Disease Associations (null)
No disease associations found
GWAS Traits (2)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
BMI-adjusted hip circumference
1
3
3
65.9
smoking status measurement
2
1
2
4.2
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
BMI-adjusted hip circumference
3
65.9
smoking status measurement
2
4.2
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (14)
1 – 5 of 14
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
dynein cytoplasmic 1 intermediate chain 2
VGNC:367
737197
Macaque
dynein cytoplasmic 1 intermediate chain 2
695696
Mouse
MGI:107750
13427
Rat
RGD:620174
116659
Dog
dynein cytoplasmic 1 intermediate chain 2
VGNC:40145
478797
Species
Name
OMA
EggNOG
Inparanoid
Chimp
dynein cytoplasmic 1 intermediate chain 2
Macaque
dynein cytoplasmic 1 intermediate chain 2
Mouse
Rat
Dog
dynein cytoplasmic 1 intermediate chain 2
Publication Statistics
PubMed Score 444.96
PubMed score by year
PubTator Score 87.44
PubTator score by year
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Related Publications
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0 of 0
PMID
Year
Title