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Tbio
DYNC1I1
Cytoplasmic dynein 1 intermediate chain 1

Protein Summary
Description
Acts as one of several non-catalytic accessory components of the cytoplasmic dynein 1 complex that are thought to be involved in linking dynein to cargos and to adapter proteins that regulate dynein function. Cytoplasmic dynein 1 acts as a motor for the intracellular retrograde motility of vesicles and organelles along microtubules. The intermediate chains mediate the binding of dynein to dynactin via its 150 kDa component (p150-glued) DCNT1. May play a role in mediating the interaction of cytoplasmic dynein with membranous organelles and kinetochores.
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000324972
  • ENSP00000320130
  • ENSG00000158560
  • ENST00000359388
  • ENSP00000352348
  • ENST00000437599
  • ENSP00000398118
  • ENST00000447467
  • ENSP00000392337
  • ENST00000457059
  • ENSP00000412444
  • ENST00000630942
  • ENSP00000486363

Symbol
  • DNCI1
  • DNCIC1
  • DNCI1
  • DNCIC1
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
gene perturbation
0.84
disease perturbation
0.79
PubMedID
0.69
trait
0.61
molecular function
0.6


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 9.05   (req: < 5)
Gene RIFs: 11   (req: <= 3)
Antibodies: 128   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 9.05   (req: >= 5)
Gene RIFs: 11   (req: > 3)
Antibodies: 128   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 10
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
No expression data found
Related Tools
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (352)
DYNC1LI2
Tbio
Novelty:  0.17381295
p_int:  0.999435532
p_ni:  0.000564468
Score:  0.996
Data Source:  BioPlex,Reactome,STRINGDB
WDR34
Tbio
Novelty:  0.05515847
p_int:  0.996383076
p_ni:  0.003616924
Score:  0.755
Data Source:  BioPlex,STRINGDB
DYNC1H1
Tbio
Novelty:  0.0098543
p_int:  0.994497295
p_ni:  0.005502705
Score:  0.997
Data Source:  BioPlex,Reactome,STRINGDB
DYNC1LI1
Tbio
Novelty:  0.02164556
p_int:  0.993888848
p_ni:  0.006111152
Score:  0.994
Data Source:  BioPlex,Reactome,STRINGDB
DISC1
Tbio
Novelty:  0.00183442
p_int:  0.981891551
p_ni:  0.018108449
Score:  0.177
Data Source:  BioPlex,STRINGDB
FAM83D
Tbio
Novelty:  0.07381559
p_int:  0.911494364
p_ni:  0.088505622
p_wrong:  1.5e-8
Score:  0.173
Data Source:  BioPlex,STRINGDB
DYNC1I2
Tbio
Novelty:  0.00228615
p_int:  0.904373514
p_ni:  0.095626486
Score:  0.987
Data Source:  BioPlex,Reactome,STRINGDB
RPL23
Tbio
Novelty:  0.02741113
p_int:  0.878257315
p_ni:  0.121742685
Data Source:  BioPlex
C15orf39
Tdark
Novelty:  1.68615093
p_int:  0.867906113
p_ni:  0.132093858
p_wrong:  3e-8
Score:  0.177
Data Source:  BioPlex,STRINGDB
SAMD1
Tdark
Novelty:  0.21956379
p_int:  0.867796119
p_ni:  0.131656242
p_wrong:  0.000547638
Data Source:  BioPlex
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (54)
Adaptive Immune System (R-HSA-1280218)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 5 of 33
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Adaptive Immune System
Reactome
Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal
Reactome
Amplification of signal from the kinetochores
Reactome
Asparagine N-linked glycosylation
Reactome
COPI-independent Golgi-to-ER retrograde traffic
Name
Explore in Pharos
Explore in Source
Adaptive Immune System
Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal
Amplification of signal from the kinetochores
Asparagine N-linked glycosylation
COPI-independent Golgi-to-ER retrograde traffic
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (23)
Find Similar Targets
Items per page:
10
1 – 6 of 6
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
MGI
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Sequence or structural Similarity (ISS)
HGNC
Inferred from Sequence or structural Similarity (ISS)
HGNC
Traceable Author Statement (TAS)
ProtInc
Disease Associations ()
No disease associations found
GWAS Traits (8)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
heel bone mineral density
2
2
3
76.2
1
1
0
1
42.3
bone density
1
1
2
35
1
1
0
1.1
35
1
1
0
1.1
35
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
heel bone mineral density
3
76.2
0
1
42.3
bone density
2
35
0
1.1
35
0
1.1
35
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (12)
1 – 5 of 12
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
dynein cytoplasmic 1 intermediate chain 1
VGNC:8678
450134
Macaque
dynein cytoplasmic 1 intermediate chain 1
574351
Mouse
MGI:107743
13426
Rat
RGD:2512
29564
Dog
dynein cytoplasmic 1 intermediate chain 1
VGNC:40144
475236
Species
Name
OMA
EggNOG
Inparanoid
Chimp
dynein cytoplasmic 1 intermediate chain 1
Macaque
dynein cytoplasmic 1 intermediate chain 1
Mouse
Rat
Dog
dynein cytoplasmic 1 intermediate chain 1
Publication Statistics
PubMed Score 9.05
PubMed score by year
PubTator Score 6.05
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title