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Tdark
DYDC2
DPY30 domain-containing protein 2

Protein Summary
Description
This gene encodes a member of a family of proteins that contains a DPY30 domain. This gene locus overlaps with a closely related gene on the opposite strand. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jun 2012]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000256039
  • ENSP00000256039
  • ENSG00000133665
  • ENST00000372197
  • ENSP00000361271
  • ENST00000372199
  • ENSP00000361273
  • ENST00000444807
  • ENSP00000410285
  • ENST00000616870
  • ENSP00000483479
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
gene perturbation
0.74
microRNA
0.54
cell line
0.53
histone modification site profile
0.53
cellular component
0.52


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 0.8   (req: < 5)
Gene RIFs: 1   (req: <= 3)
Antibodies: 127   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 0.8   (req: >= 5)
Gene RIFs: 1   (req: > 3)
Antibodies: 127   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Term: 1
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
No expression data found
Related Tools
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (43)
SCRN3
Tbio
Family:  Enzyme
Novelty:  0.03516382
p_int:  0.999952581
p_ni:  0.000037841
p_wrong:  0.000009578
Data Source:  BioPlex
INPPL1
Tchem
Family:  Enzyme
Novelty:  0.00634126
p_int:  0.999938202
p_ni:  0.000061798
Data Source:  BioPlex
DLGAP5
Tbio
Novelty:  0.01673312
p_int:  0.999724492
p_ni:  0.000275484
p_wrong:  2.4e-8
Data Source:  BioPlex
ARHGEF12
Tchem
Novelty:  0.01365866
p_int:  0.9959031
p_ni:  0.004096898
p_wrong:  2e-9
Data Source:  BioPlex
NME5
Tbio
Family:  Kinase
Novelty:  0.08755237
p_int:  0.99359429
p_wrong:  0.00640571
Score:  0.755
Data Source:  BioPlex,STRINGDB
TGFBRAP1
Tbio
Novelty:  0.05996919
p_int:  0.807718071
p_ni:  0.191723797
p_wrong:  0.000558131
Data Source:  BioPlex
SH2D4B
Tdark
Novelty:  1.34545865
Score:  0.722
Data Source:  STRINGDB
SPTSSA
Tbio
Family:  Enzyme
Novelty:  0.13352078
Score:  0.646
Data Source:  STRINGDB
DYDC1
Tdark
Novelty:  0.35666983
Score:  0.622
Data Source:  STRINGDB
TSPAN14
Tdark
Novelty:  0.31693614
Score:  0.589
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (0)
No pathways found
Viral Interactions (0)
No viral interactions found
Disease Associations ()
No disease associations found
GWAS Traits (12)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
hematocrit
2
2
2
67.9
pulse pressure measurement
1
1
1
62.1
vitamin D measurement
4
3
4
58.9
hemoglobin measurement
2
2
2
49.5
intraocular pressure measurement
1
1
1
35
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
hematocrit
2
67.9
pulse pressure measurement
1
62.1
vitamin D measurement
4
58.9
hemoglobin measurement
2
49.5
intraocular pressure measurement
1
35
IDG Resources
No IDG generated resources found
Orthologs (9)
1 – 5 of 9
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
DPY30 domain containing 2
VGNC:3841
450557
Macaque
DPY30 domain containing 2
706473
Mouse
MGI:1918450
71200
Rat
RGD:1588866
688422
Dog
DPY30 domain containing 2
VGNC:50874
610554
Species
Name
OMA
EggNOG
Inparanoid
Chimp
DPY30 domain containing 2
Macaque
DPY30 domain containing 2
Mouse
Rat
Dog
DPY30 domain containing 2
Publication Statistics
PubMed Score 0.80
PubMed score by year
PubTator Score 0.50
PubTator score by year
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Related Publications
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0 of 0
PMID
Year
Title