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Tbio
DXO
Decapping and exoribonuclease protein

Protein Summary
Description
Ribonuclease that specifically degrades pre-mRNAs with a defective 5' end cap and is part of a pre-mRNA capping quality control. Has decapping, pyrophosphohydrolase and 5'-3' exonuclease activities. Has decapping activity toward incomplete 5' end cap mRNAs such as unmethylated 5' end-capped RNA to release GpppN and 5' end monophosphate RNA. The 5' end monophosphate RNA is then degraded by the 5'-3' exoribonuclease activity, enabling this enzyme to decap and degrade incompletely capped mRNAs. Also possesses RNA 5'-pyrophosphohydrolase activity by hydrolyzing the 5' end triphosphate to release pyrophosphates (By similarity). This gene localizes to the major histocompatibility complex (MHC) class III region on chromosome 6. The function of its protein product is unknown, but its ubiquitous expression and conservation in both simple and complex eukaryotes suggests that this may be a housekeeping gene. [provided by RefSeq, Jul 2008]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000337523
  • ENSP00000337759
  • ENSG00000204348
  • ENST00000375349
  • ENSP00000364498
  • ENST00000375356
  • ENSP00000364505
  • ENST00000383330
  • ENSP00000372820
  • ENSG00000206346
  • ENST00000399936
  • ENSP00000382818
  • ENST00000399937
  • ENSP00000382819
  • ENST00000414092
  • ENSP00000391123
  • ENSG00000236765
  • ENST00000419797
  • ENSP00000391532
  • ENSG00000234798
  • ENST00000426498
  • ENSP00000394167
  • ENSG00000225682
  • ENST00000427627
  • ENSP00000413860
  • ENST00000427690
  • ENSP00000406143
  • ENST00000432110
  • ENSP00000401315
  • ENST00000439989
  • ENSP00000395262
  • ENSG00000224313
  • ENST00000443250
  • ENSP00000415675
  • ENST00000446967
  • ENSP00000391349
  • ENST00000453742
  • ENSP00000410404
  • ENST00000454430
  • ENSP00000411380
  • ENST00000458308
  • ENSP00000400173

Symbol
  • DOM3L
  • DOM3Z
  • NG6
  • NG6
  • RAI1
  • DOM3L
  • DOM3Z
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
histone modification site profile
0.92
molecular function
0.84
transcription factor binding site profile
0.74
transcription factor
0.66
tissue sample
0.65


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 61.98   (req: < 5)
Gene RIFs: 4   (req: <= 3)
Antibodies: 118   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 61.98   (req: >= 5)
Gene RIFs: 4   (req: > 3)
Antibodies: 118   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 9
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0