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Tdark
DUXA
Double homeobox protein A

Protein Summary
Description
Putative transcription factor. Homeobox genes encode DNA-binding proteins, many of which are thought to be involved in early embryonic development. Homeobox genes encode a DNA-binding domain of 60 to 63 amino acids referred to as the homeodomain. This gene is a member of the DUXA homeobox gene family. Evidence of mRNA expression has not yet been found for this gene. Multiple, related processed pseudogenes have been found which are thought to reflect expression of this gene in the germ line or embryonic cells. [provided by RefSeq, Jul 2008]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000554048
  • ENSP00000452398
  • ENSG00000258873
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
cell line
0.63
tissue
0.56
microRNA
0.49
biological process
0.41
chemical
0.41


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 11.87   (req: < 5)
Gene RIFs: 0   (req: <= 3)
Antibodies: 28   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 11.87   (req: >= 5)
Gene RIFs: 0   (req: > 3)
Antibodies: 28   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 2
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (38)
TPRX1
Tbio
Novelty:  0.4834652
Score:  0.803
Data Source:  STRINGDB
LEUTX
Tdark
Family:  TF
Novelty:  0.20538904
Score:  0.797
Data Source:  STRINGDB
ARGFX
Tdark
Family:  TF
Novelty:  0.84035526
Score:  0.797
Data Source:  STRINGDB
ADAT1
Tbio
Family:  Enzyme
Novelty:  0.07060317
Score:  0.738
Data Source:  STRINGDB
VENTX
Tbio
Family:  TF
Novelty:  0.09005259
Score:  0.722
Data Source:  STRINGDB
TERF2IP
Tchem
Novelty:  0.06285957
Score:  0.707
Data Source:  STRINGDB
ANXA11
Tbio
Novelty:  0.00925429
Score:  0.668
Data Source:  STRINGDB
PEPD
Tchem
Family:  Enzyme
Novelty:  0.00141261
Score:  0.623
Data Source:  STRINGDB
ZNF835
Tdark
Family:  TF
Novelty:  2.91666667
Score:  0.591
Data Source:  STRINGDB
NT5C1B
Tbio
Family:  Enzyme
Novelty:  0.09140009
Score:  0.58
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (0)
No pathways found
Viral Interactions (0)
No viral interactions found
Disease Associations (null)
No disease associations found
GWAS Traits (1)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
Dupuytren Contracture
2
1
0
1.3
88
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
Dupuytren Contracture
0
1.3
88
IDG Resources
No IDG generated resources found
Orthologs (4)
1 – 4 of 4
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
double homeobox A
VGNC:11000
469032
Macaque
double homeobox A
709447
Dog
double homeobox A [Source:HGNC Symbol;Acc:HGNC:32179]
Horse
double homeobox A
VGNC:17361
100059378
Species
Name
OMA
EggNOG
Inparanoid
Chimp
double homeobox A
Macaque
double homeobox A
Dog
double homeobox A [Source:HGNC Symbol;Acc:HGNC:32179]
Horse
double homeobox A
Publication Statistics
PubMed Score 11.87
PubMed score by year
PubTator Score 0.78
PubTator score by year
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Related Publications
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PMID
Year
Title