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Tbio
DUSP23
Dual specificity protein phosphatase 23

Protein Summary
Description
Protein phosphatase that mediates dephosphorylation of proteins phosphorylated on Tyr and Ser/Thr residues. In vitro, it can dephosphorylate p44-ERK1 (MAPK3) but not p54 SAPK-beta (MAPK10) in vitro. Able to enhance activation of JNK and p38 (MAPK14).
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000368107
  • ENSP00000357087
  • ENSG00000158716
  • ENST00000368108
  • ENSP00000357088
  • ENST00000368109
  • ENSP00000357089

Symbol
  • LDP3
  • VHZ
  • VHZ
  • LDP3
  • MOSP
  • LDP-3
  • DUSP25
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
histone modification site profile
0.78
virus perturbation
0.72
transcription factor binding site profile
0.69
protein domain
0.58
transcription factor
0.56


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 17.03   (req: < 5)
Gene RIFs: 6   (req: <= 3)
Antibodies: 168   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 17.03   (req: >= 5)
Gene RIFs: 6   (req: > 3)
Antibodies: 168   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 5
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
No expression data found
Related Tools
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (74)
SUGP1
Tbio
Novelty:  0.00434166
p_int:  0.998391354
p_ni:  0.001608646
Score:  0.167
Data Source:  BioPlex,STRINGDB
ERICH5
Tdark
Novelty:  5.57504212
p_int:  0.995655044
p_ni:  0.004344955
p_wrong:  1e-9
Data Source:  BioPlex
C1orf131
Tdark
Novelty:  10.11904762
p_int:  0.991988768
p_ni:  0.008011231
p_wrong:  1e-9
Score:  0.187
Data Source:  BioPlex,STRINGDB
RBM27
Tdark
Novelty:  0.04875536
p_int:  0.988069515
p_ni:  0.011930485
Score:  0.186
Data Source:  BioPlex,STRINGDB
DNM1L
Tchem
Novelty:  0.00151314
p_int:  0.939316962
p_ni:  0.050209414
p_wrong:  0.010473624
Score:  0.176
Data Source:  BioPlex,STRINGDB
CTNNBL1
Tbio
Novelty:  0.0189038
p_int:  0.936106992
p_ni:  0.042431571
p_wrong:  0.021461437
Score:  0.195
Data Source:  BioPlex,STRINGDB
PRRC2A
Tbio
Novelty:  0.01493149
p_int:  0.934585121
p_ni:  0.065411509
p_wrong:  0.00000337
Score:  0.183
Data Source:  BioPlex,STRINGDB
AHNAK2
Tbio
Novelty:  0.05663435
p_int:  0.92029128
p_ni:  0.079707015
p_wrong:  0.000001705
Score:  0.177
Data Source:  BioPlex,STRINGDB
IK
Tbio
Novelty:  0.01510642
p_int:  0.902498595
p_ni:  0.097501359
p_wrong:  4.6e-8
Score:  0.161
Data Source:  BioPlex,STRINGDB
SCYL1
Tbio
Family:  Kinase
Novelty:  0.03774351
p_int:  0.895706964
p_ni:  0.102261109
p_wrong:  0.002031927
Score:  0.189
Data Source:  BioPlex,STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (0)
No pathways found
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (8)
Find Similar Targets
Items per page:
10
1 – 4 of 4
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Disease Associations ()
No disease associations found
GWAS Traits (11)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
C-reactive protein measurement
21
38
55
4
100
erythropoetin measurement
1
1
1
75.5
waist-hip ratio
1
1
1
49.5
BMI-adjusted waist-hip ratio
1
1
1
47.7
waist circumference
1
1
1
40.7
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
C-reactive protein measurement
55
4
100
erythropoetin measurement
1
75.5
waist-hip ratio
1
49.5
BMI-adjusted waist-hip ratio
1
47.7
waist circumference
1
40.7
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (10)
1 – 5 of 10
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
dual specificity phosphatase 23
VGNC:524
746364
Macaque
dual specificity phosphatase 23
719474
Mouse
MGI:1915690
68440
Rat
RGD:1309202
360881
Horse
dual specificity phosphatase 23
VGNC:17354
100053524
Species
Name
OMA
EggNOG
Inparanoid
Chimp
dual specificity phosphatase 23
Macaque
dual specificity phosphatase 23
Mouse
Rat
Horse
dual specificity phosphatase 23
Publication Statistics
PubMed Score 17.03
PubMed score by year
PubTator Score 18.13
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title