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Tbio
DUSP22
Dual specificity protein phosphatase 22

Protein Summary
Description
Activates the Jnk signaling pathway. Dephosphorylates and deactivates p38 and stress-activated protein kinase/c-Jun N-terminal kinase (SAPK/JNK) (By similarity).
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000344450
  • ENSP00000345281
  • ENSG00000112679
  • ENST00000419235
  • ENSP00000397459

Symbol
  • JSP1
  • LMWDSP2
  • MKPX
  • VHX
  • JKAP
  • JSP1
  • MKPX
  • JSP-1
  • MKP-x
  • LMWDSP2
  • LMW-DSP2
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
transcription factor perturbation
0.91
biological process
0.87
protein domain
0.85
kinase perturbation
0.84
transcription factor
0.69


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 108.52   (req: < 5)
Gene RIFs: 15   (req: <= 3)
Antibodies: 290   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 108.52   (req: >= 5)
Gene RIFs: 15   (req: > 3)
Antibodies: 290   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 21
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (90)
DIABLO
Tbio
Novelty:  0.0007851
p_int:  0.999996954
p_ni:  2.65e-7
p_wrong:  0.000002781
Data Source:  BioPlex
GNA14
Tbio
Novelty:  0.0587776
p_int:  0.999631952
p_ni:  0.000368045
p_wrong:  3e-9
Score:  0.27
Data Source:  BioPlex,STRINGDB
NRN1
Tbio
Novelty:  0.01198116
p_int:  0.999259571
p_ni:  0.000715971
p_wrong:  0.000024458
Data Source:  BioPlex
CCNYL1
Tdark
Novelty:  0.45350824
p_int:  0.999237945
p_ni:  0.000761948
p_wrong:  1.07e-7
Score:  0.21
Data Source:  BioPlex,STRINGDB
LARS2
Tbio
Family:  Enzyme
Novelty:  0.00543895
p_int:  0.996462457
p_ni:  0.003537543
Score:  0.179
Data Source:  BioPlex,STRINGDB
GNAQ
Tbio
Novelty:  0.0008997
p_int:  0.992963483
p_ni:  0.00703648
p_wrong:  3.6e-8
Data Source:  BioPlex
CALML3
Tbio
Novelty:  0.0336689
p_int:  0.99269039
p_ni:  4e-8
p_wrong:  0.007309571
Score:  0.163
Data Source:  BioPlex,STRINGDB
HPCAL1
Tbio
Novelty:  0.04434155
p_int:  0.988071646
p_ni:  0.011358279
p_wrong:  0.000570075
Score:  0.227
Data Source:  BioPlex,STRINGDB
ERICH5
Tdark
Novelty:  5.57504212
p_int:  0.986000276
p_ni:  0.013996316
p_wrong:  0.000003408
Data Source:  BioPlex
OCC1
Tbio
Novelty:  0.05175429
p_int:  0.983669162
p_ni:  0.014257561
p_wrong:  0.002073276
Data Source:  BioPlex
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (27)
Find Similar Targets
Items per page:
10
1 – 4 of 4
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
ARUK-UCL
Inferred from Direct Assay (IDA)
ARUK-UCL
Inferred from Physical Interaction (IPI)
ARUK-UCL
Inferred from Electronic Annotation (IEA)
InterPro
Disease Associations (null)
No disease associations found
GWAS Traits (54)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
hair color
8
10
3
1.2
99.9
hair colour measurement
3
4
4
98.7
6
3
0
1.4
97.4
cutaneous squamous cell carcinoma
2
1
1
1.6
95.9
1
3
3
95.4
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
hair color
3
1.2
99.9
hair colour measurement
4
98.7
0
1.4
97.4
cutaneous squamous cell carcinoma
1
1.6
95.9
3
95.4
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (12)
1 – 5 of 12
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
dual specificity phosphatase 22
VGNC:11062
750495
Macaque
dual specificity phosphatase 22
705824
Mouse
MGI:1915926
105352
Rat
RGD:1307146
361242
Dog
dual specificity phosphatase 22
VGNC:40133
606970
Species
Name
OMA
EggNOG
Inparanoid
Chimp
dual specificity phosphatase 22
Macaque
dual specificity phosphatase 22
Mouse
Rat
Dog
dual specificity phosphatase 22
Publication Statistics
PubMed Score 108.52
PubMed score by year
PubTator Score 30.11
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title