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Tbio
DUSP16
Dual specificity protein phosphatase 16

Protein Summary
Description
Dual specificity protein phosphatase involved in the inactivation of MAP kinases. Dephosphorylates MAPK10 bound to ARRB2. This gene encodes a mitogen-activated protein kinase phosphatase that is a member of the dual specificity protein phosphatase subfamily. These phosphatases inactivate their target kinases by dephosphorylating both the phosphoserine/threonine and phosphotyrosine residues. The encoded protein specifically regulates the c-Jun amino-terminal kinase (JNK) and extracellular signal-regulated kinase (ERK) pathways.[provided by RefSeq, May 2010]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000228862
  • ENSP00000228862
  • ENSG00000111266
  • ENST00000298573
  • ENSP00000298573
  • ENST00000626413
  • ENSP00000487512
  • ENSG00000280962
  • ENST00000628303
  • ENSP00000487034

Symbol
  • KIAA1700
  • MKP7
  • MKP7
  • MKP-7
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
protein domain
0.97
virus perturbation
0.92
transcription factor binding site profile
0.86
transcription factor perturbation
0.84
drug perturbation
0.71


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 39.38   (req: < 5)
Gene RIFs: 16   (req: <= 3)
Antibodies: 203   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 39.38   (req: >= 5)
Gene RIFs: 16   (req: > 3)
Antibodies: 203   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 10
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
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TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (34)
MAPK14
Tchem
Family:  Kinase
Novelty:  0.00045138
p_int:  0.999643315
p_ni:  0.000040285
p_wrong:  0.0003164
Score:  0.994
Data Source:  BioPlex,STRINGDB
MAPK8
Tchem
Family:  Kinase
Novelty:  0.00055723
Score:  0.997
Data Source:  STRINGDB
MAPK1
Tchem
Family:  Kinase
Novelty:  0.00061058
Score:  0.994
Data Source:  STRINGDB
MAPK11
Tchem
Family:  Kinase
Novelty:  0.00545217
Score:  0.974
Data Source:  STRINGDB
MAPK10
Tchem
Family:  Kinase
Novelty:  0.00420573
Score:  0.974
Data Source:  STRINGDB
MAPK3
Tchem
Family:  Kinase
Novelty:  0.00012969
Score:  0.955
Data Source:  STRINGDB
MAPK9
Tchem
Family:  Kinase
Novelty:  0.00267199
Score:  0.938
Data Source:  STRINGDB
MAPK13
Tchem
Family:  Kinase
Novelty:  0.01071621
Score:  0.863
Data Source:  STRINGDB
MAPK12
Tchem
Family:  Kinase
Novelty:  0.00835017
Score:  0.859
Data Source:  STRINGDB
TWISTNB
Tdark
Family:  Enzyme
Novelty:  0.59160737
Score:  0.792
Data Source:  STRINGDB
Pathways (295)
Cytokine Signaling in Immune system (R-HSA-1280215)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 5 of 11
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Cytokine Signaling in Immune system
Reactome
FLT3 Signaling
Reactome
Immune System
Reactome
MAPK family signaling cascades
Reactome
MAPK1/MAPK3 signaling
Name
Explore in Pharos
Explore in Source
Cytokine Signaling in Immune system
FLT3 Signaling
Immune System
MAPK family signaling cascades
MAPK1/MAPK3 signaling
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (15)
Find Similar Targets
Items per page:
10
1 – 5 of 5
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Traceable Author Statement (TAS)
UniProtKB
Inferred from Electronic Annotation (IEA)
UniProtKB-EC
Disease Associations (null)
No disease associations found
GWAS Traits (9)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
balding measurement
1
1
1
54.4
lymphocyte percentage of leukocytes
1
1
1
46.9
lymphocyte count
1
1
1
46.1
neutrophil percentage of leukocytes
1
1
1
44.2
1
1
0
1.1
24.5
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
balding measurement
1
54.4
lymphocyte percentage of leukocytes
1
46.9
lymphocyte count
1
46.1
neutrophil percentage of leukocytes
1
44.2
0
1.1
24.5
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (11)
1 – 5 of 11
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
dual specificity phosphatase 16
VGNC:51252
465297
Macaque
dual specificity phosphatase 16
696332
Mouse
MGI:1917936
70686
Rat
RGD:1310721
297682
Dog
dual specificity phosphatase 16
VGNC:40130
486683
Species
Name
OMA
EggNOG
Inparanoid
Chimp
dual specificity phosphatase 16
Macaque
dual specificity phosphatase 16
Mouse
Rat
Dog
dual specificity phosphatase 16
Publication Statistics
PubMed Score 39.38
PubMed score by year
PubTator Score 21.66
PubTator score by year
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Related Publications
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0 of 0
PMID
Year
Title