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Tbio
DUSP14
Dual specificity protein phosphatase 14

Protein Summary
Description
Involved in the inactivation of MAP kinases. Dephosphorylates ERK, JNK and p38 MAP-kinases. Dual-specificity phosphatases (DUSPs) constitute a large heterogeneous subgroup of the type I cysteine-based protein-tyrosine phosphatase superfamily. DUSPs are characterized by their ability to dephosphorylate both tyrosine and serine/threonine residues. They have been implicated as major modulators of critical signaling pathways. DUSP14 contains the consensus DUSP C-terminal catalytic domain but lacks the N-terminal CH2 domain found in the MKP (mitogen-activated protein kinase phosphatase) class of DUSPs (see MIM 600714) (summary by Patterson et al., 2009 [PubMed 19228121]).[supplied by OMIM, Dec 2009]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000613659
  • ENSP00000484091
  • ENSG00000276023
  • ENST00000614294
  • ENSP00000478406
  • ENSG00000275932
  • ENST00000614411
  • ENSP00000477653
  • ENST00000617516
  • ENSP00000478595
  • ENST00000632468
  • ENSP00000487886
  • ENST00000633870
  • ENSP00000488882

Symbol
  • MKP6
  • MKP6
  • MKP-L
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
protein domain
0.97
gene perturbation
0.86
transcription factor binding site profile
0.86
kinase perturbation
0.81
PubMedID
0.81


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 30.01   (req: < 5)
Gene RIFs: 9   (req: <= 3)
Antibodies: 326   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 30.01   (req: >= 5)
Gene RIFs: 9   (req: > 3)
Antibodies: 326   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 3
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
No expression data found
Related Tools
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (77)
CPLX3
Tbio
Novelty:  0.07332857
p_int:  0.999843281
p_ni:  0.000156719
Data Source:  BioPlex
MAS1
Tchem
Family:  GPCR
Novelty:  0.0089712
p_int:  0.999658732
p_ni:  0.000341259
p_wrong:  9e-9
Data Source:  BioPlex
SMARCD1
Tbio
Novelty:  0.03176642
p_int:  0.999652871
p_ni:  0.000347074
p_wrong:  5.5e-8
Data Source:  BioPlex
OAZ3
Tbio
Family:  Enzyme
Novelty:  0.02374168
p_int:  0.999606701
p_ni:  0.000393299
Data Source:  BioPlex
KIF3A
Tbio
Novelty:  0.00555124
p_int:  0.999534526
p_ni:  0.000465474
Score:  0.195
Data Source:  BioPlex,STRINGDB
SGO2
Tbio
Novelty:  0.05544423
p_int:  0.999524411
p_ni:  0.000470419
p_wrong:  0.00000517
Data Source:  BioPlex
FBXL4
Tbio
Novelty:  0.04286856
p_int:  0.999498123
p_ni:  0.000501876
p_wrong:  1e-9
Data Source:  BioPlex
IL31RA
Tbio
Novelty:  0.00737445
p_int:  0.999323028
p_ni:  0.000676965
p_wrong:  7e-9
Data Source:  BioPlex
B3GALNT1
Tbio
Family:  Enzyme
Novelty:  0.01235828
p_int:  0.998807996
p_ni:  0.001192003
Data Source:  BioPlex
SYT16
Tbio
Novelty:  0.05270686
p_int:  0.998219357
p_ni:  0.001780641
p_wrong:  2e-9
Data Source:  BioPlex
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Viral Interactions (0)
No viral interactions found
Disease Associations ()
No disease associations found
GWAS Traits (28)
Items per page:
1 – 5 of 28
GWAS Trait
EFO ID
ENSG ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
monocyte count
2
1
2
82.4
monocyte count
2
1
2
82.4
lymphocyte count
2
2
2
81.7
lymphocyte count
2
2
2
81.7
platelet crit
2
2
2
75.9
Items per page:
1 – 5 of 28
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
monocyte count
2
82.4
monocyte count
2
82.4
lymphocyte count
2
81.7
lymphocyte count
2
81.7
platelet crit
2
75.9
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (11)
1 – 5 of 11
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Macaque
dual specificity phosphatase 14
714383
Mouse
MGI:1927168
56405
Rat
RGD:1590821
365977
Dog
dual specificity phosphatase 14
VGNC:40129
491131
Horse
dual specificity phosphatase 14
VGNC:17350
100057681
Species
Name
OMA
EggNOG
Inparanoid
Macaque
dual specificity phosphatase 14
Mouse
Rat
Dog
dual specificity phosphatase 14
Horse
dual specificity phosphatase 14
Publication Statistics
PubMed Score 30.01
PubMed score by year
PubTator Score 7.39
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title