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Tdark
DUS3L
tRNA-dihydrouridine(47) synthase [NAD(P)(+)]-like

Protein Summary
Description
Catalyzes the synthesis of dihydrouridine, a modified base found in the D-loop of most tRNAs.
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000309061
  • ENSP00000311977
  • ENSG00000141994
  • ENST00000320699
  • ENSP00000315558

Symbol
  • DUS3
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
kinase perturbation
0.91
transcription factor binding site profile
0.91
transcription factor
0.87
interacting protein
0.81
histone modification site profile
0.77


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 4.55   (req: < 5)
Gene RIFs: 0   (req: <= 3)
Antibodies: 84   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 4.55   (req: >= 5)
Gene RIFs: 0   (req: > 3)
Antibodies: 84   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 4
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (95)
C1QL4
Tdark
Novelty:  0.37071722
p_int:  0.99999992
p_ni:  7.8e-8
p_wrong:  3e-9
Score:  0.174
Data Source:  BioPlex,STRINGDB
SARS
Tbio
Family:  Enzyme
Novelty:  0.00963508
p_int:  0.999993917
p_ni:  0.000006057
p_wrong:  2.6e-8
Score:  0.417
Data Source:  BioPlex,STRINGDB
NCAPH2
Tbio
Novelty:  0.12134933
p_int:  0.999576813
p_ni:  0.000399643
p_wrong:  0.000023544
Score:  0.162
Data Source:  BioPlex,STRINGDB
AVIL
Tbio
Novelty:  0.0175973
p_int:  0.998378062
p_ni:  0.001605697
p_wrong:  0.000016241
Score:  0.167
Data Source:  BioPlex,STRINGDB
CDC16
Tbio
Novelty:  0.00916715
p_int:  0.996341826
p_ni:  0.003273648
p_wrong:  0.000384527
Data Source:  BioPlex
EIF1AD
Tdark
Novelty:  0.23915521
p_int:  0.945534056
p_ni:  0.054380255
p_wrong:  0.000085689
Data Source:  BioPlex
BOP1
Tbio
Novelty:  0.03512044
Score:  0.781
Data Source:  STRINGDB
TRMT6
Tbio
Family:  Enzyme
Novelty:  0.06718902
Score:  0.736
Data Source:  STRINGDB
ABHD17A
Tbio
Family:  Enzyme
Novelty:  0.26144756
Score:  0.73
Data Source:  STRINGDB
REXO1
Tdark
Family:  Enzyme
Novelty:  0.23817911
Score:  0.718
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (0)
No pathways found
Viral Interactions (0)
No viral interactions found
Disease Associations (null)
No disease associations found
GWAS Traits (26)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
cancer biomarker measurement
1
3
4
97
cancer antigen 19.9 measurement
1
2
2
91
vitamin B12 measurement
2
3
2
49.8
88.8
N-glycan measurement
2
1
18
79.4
aspartate aminotransferase measurement
1
1
0
10.1
76
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
cancer biomarker measurement
4
97
cancer antigen 19.9 measurement
2
91
vitamin B12 measurement
2
49.8
88.8
N-glycan measurement
18
79.4
aspartate aminotransferase measurement
0
10.1
76
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (12)
1 – 5 of 12
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
dihydrouridine synthase 3 like
VGNC:7689
739498
Mouse
MGI:2147092
224907
Rat
RGD:1563228
301122
Dog
dihydrouridine synthase 3 like
VGNC:54596
100856098
Cow
dihydrouridine synthase 3 like
508812
Species
Name
OMA
EggNOG
Inparanoid
Chimp
dihydrouridine synthase 3 like
Mouse
Rat
Dog
dihydrouridine synthase 3 like
Cow
dihydrouridine synthase 3 like
Publication Statistics
PubMed Score 4.55
PubMed score by year
PubTator Score 0.07
PubTator score by year
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Related Publications
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PMID
Year
Title