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Tdark
DTWD1
DTW domain-containing protein 1

Protein Summary
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000251250
  • ENSP00000251250
  • ENSG00000104047
  • ENST00000403028
  • ENSP00000385399
  • ENST00000557968
  • ENSP00000452628
  • ENST00000558653
  • ENSP00000453529

Symbol
  • MDS009
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
kinase perturbation
0.95
transcription factor binding site profile
0.93
transcription factor perturbation
0.84
histone modification site profile
0.83
virus perturbation
0.76


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 2.58   (req: < 5)
Gene RIFs: 0   (req: <= 3)
Antibodies: 114   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 2.58   (req: >= 5)
Gene RIFs: 0   (req: > 3)
Antibodies: 114   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Term: 0
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (20)
SPACA1
Tbio
Novelty:  0.07415851
p_int:  0.990515403
p_ni:  0.005933522
p_wrong:  0.003551076
Score:  0.224
Data Source:  BioPlex,STRINGDB
TMC2
Tbio
Family:  IC
Novelty:  0.03655557
Score:  0.762
Data Source:  STRINGDB
SECISBP2L
Tdark
Novelty:  0.03341871
Score:  0.677
Data Source:  STRINGDB
SPEF1
Tdark
Novelty:  0.14564815
Score:  0.548
Data Source:  STRINGDB
ALG9
Tbio
Family:  Enzyme
Novelty:  0.02975572
Score:  0.534
Data Source:  STRINGDB
TMC1
Tbio
Family:  IC
Novelty:  0.00609628
Score:  0.53
Data Source:  STRINGDB
TSR3
Tdark
Novelty:  0.09337944
Score:  0.499
Data Source:  STRINGDB
SPPL2A
Tchem
Family:  Enzyme
Novelty:  0.02899909
Score:  0.494
Data Source:  STRINGDB
PLAC9
Tdark
Novelty:  0.23764669
Score:  0.491
Data Source:  STRINGDB
ABCB8
Tbio
Family:  Transporter
Novelty:  0.08074055
Score:  0.487
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (0)
No pathways found
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (0)
No GO Terms found
Disease Associations (null)
No disease associations found
GWAS Traits (7)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
low density lipoprotein cholesterol measurement
2
2
2
64.2
serum gamma-glutamyl transferase measurement
1
1
1
54.4
apolipoprotein B measurement
1
1
1
37.6
1
2
0
1.1
35
aspartate aminotransferase measurement
1
1
0
5.8
26.1
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
low density lipoprotein cholesterol measurement
2
64.2
serum gamma-glutamyl transferase measurement
1
54.4
apolipoprotein B measurement
1
37.6
0
1.1
35
aspartate aminotransferase measurement
0
5.8
26.1
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (15)
1 – 5 of 15
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
DTW domain containing 1
VGNC:2482
453420
Mouse
MGI:1916435
69185
Rat
RGD:1311144
296119
Dog
DTW domain containing 1
VGNC:40115
100687990
Horse
DTW domain containing 1
VGNC:17335
100055565
Species
Name
OMA
EggNOG
Inparanoid
Chimp
DTW domain containing 1
Mouse
Rat
Dog
DTW domain containing 1
Horse
DTW domain containing 1
Publication Statistics
PubMed Score 2.58
PubMed score by year
PubTator Score 0.87
PubTator score by year
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Related Publications
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PMID
Year
Title