Protein Summary
This gene encodes dystrobrevin beta, a component of the dystrophin-associated protein complex (DPC). The DPC consists of dystrophin and several integral and peripheral membrane proteins, including dystroglycans, sarcoglycans, syntrophins and dystrobrevin alpha and beta. The DPC localizes to the sarcolemma and its disruption is associated with various forms of muscular dystrophy. Dystrobrevin beta is thought to interact with syntrophin and the DP71 short form of dystrophin. [provided by RefSeq, Mar 2016]
- ENST00000404103
- ENSP00000385482
- ENSG00000138101
- ENST00000405222
- ENSP00000384787
- ENST00000406818
- ENSP00000384084
- ENST00000407038
- ENSP00000384767
- ENST00000407661
- ENSP00000385193
- ENST00000496972
- ENSP00000444463
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
|---|---|---|---|
transcription factor | 0.84 | ||
histone modification site profile | 0.8 | ||
kinase perturbation | 0.76 | ||
transcription factor binding site profile | 0.76 | ||
trait | 0.75 | ||
Protein Classes
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 14.99 (req: < 5)
Gene RIFs: 3 (req: <= 3)
Antibodies: 234 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 14.99 (req: >= 5)
Gene RIFs: 3 (req: > 3)
Antibodies: 234 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Term: 1
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligand: 0
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
Related Tools
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
Active Ligands (0)
Protein-Protein Interactions (61)
SNTG2
Novelty: 0.04056715
p_int: 0.999999996
p_ni: 4e-9
Score: 0.95
Data Source: BioPlex,STRINGDB
SNTA1
Novelty: 0.01668288
p_int: 0.999999996
p_ni: 3e-9
Score: 0.81
Data Source: BioPlex,STRINGDB
SNTB1
Novelty: 0.05324344
p_int: 0.999999965
p_ni: 3.5e-8
Score: 0.684
Data Source: BioPlex,STRINGDB
SNTG1
Novelty: 0.05608114
p_int: 0.999999845
p_ni: 1.55e-7
Score: 0.885
Data Source: BioPlex,STRINGDB
DMD
Novelty: 0.00025661
p_int: 0.999999787
p_ni: 2.11e-7
p_wrong: 2e-9
Score: 0.791
Data Source: BioPlex,STRINGDB
SNTB2
Novelty: 0.05469501
p_int: 0.999997981
p_ni: 0.000002019
Score: 0.718
Data Source: BioPlex,STRINGDB
UTRN
Novelty: 0.0018541
p_int: 0.999997
p_ni: 0.000002999
p_wrong: 1e-9
Score: 0.72
Data Source: BioPlex,STRINGDB
Nearest Tclin Targets
Pathways (0)
Viral Interactions (0)
Gene Ontology Terms (2)
Functions (1)
Components (1)
GO Term | Evidence | Assigned by | ||
|---|---|---|---|---|
Inferred from Electronic Annotation (IEA) | InterPro | |||
Disease Associations ()
GWAS Traits (21)
Items per page:
1 – 5 of 21
GWAS Trait | EFO ID | Study Count | SNP Count | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
|---|---|---|---|---|---|---|---|---|---|
BMI-adjusted waist circumference | 1 | 7 | 7 | 88.7 | |||||
waist-hip ratio | 1 | 6 | 6 | 82.9 | |||||
BMI-adjusted waist-hip ratio | 2 | 4 | 5 | 82.6 | |||||
waist circumference | 1 | 4 | 4 | 76.9 | |||||
3 | 2 | 2 | 1 | 67.5 | |||||
Items per page:
1 – 5 of 21
GWAS Trait | EFO ID | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
|---|---|---|---|---|---|---|---|
BMI-adjusted waist circumference | 7 | 88.7 | |||||
waist-hip ratio | 6 | 82.9 | |||||
BMI-adjusted waist-hip ratio | 5 | 82.6 | |||||
waist circumference | 4 | 76.9 | |||||
2 | 1 | 67.5 | |||||
Find similar targets by:
IDG Resources
Orthologs (12)
1 – 5 of 12
Species | Name | Source ID | Gene ID | OMA | EggNOG | Inparanoid | ||
|---|---|---|---|---|---|---|---|---|
Chimp | dystrobrevin beta | VGNC:232 | 459076 | |||||
Macaque | dystrobrevin beta | 696167 | ||||||
Mouse | MGI:1203728 | 13528 | ||||||
Rat | RGD:1309579 | 362715 | ||||||
Dog | dystrobrevin beta | 482997 | ||||||
Species | Name | OMA | EggNOG | Inparanoid | ||
|---|---|---|---|---|---|---|
Chimp | dystrobrevin beta | |||||
Macaque | dystrobrevin beta | |||||
Mouse | ||||||
Rat | ||||||
Dog | dystrobrevin beta | |||||
Publication Statistics
PubMed Score 14.99
PubMed score by year
PubTator Score 217.50
PubTator score by year
Related Publications
Text Mined References (27)
GeneRif Annotations (3)
Items per page:
0 of 0
PMID | Year | Title |
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