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Tbio
DTNB
Dystrobrevin beta

Protein Summary
Description
This gene encodes dystrobrevin beta, a component of the dystrophin-associated protein complex (DPC). The DPC consists of dystrophin and several integral and peripheral membrane proteins, including dystroglycans, sarcoglycans, syntrophins and dystrobrevin alpha and beta. The DPC localizes to the sarcolemma and its disruption is associated with various forms of muscular dystrophy. Dystrobrevin beta is thought to interact with syntrophin and the DP71 short form of dystrophin. [provided by RefSeq, Mar 2016]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000404103
  • ENSP00000385482
  • ENSG00000138101
  • ENST00000405222
  • ENSP00000384787
  • ENST00000406818
  • ENSP00000384084
  • ENST00000407038
  • ENSP00000384767
  • ENST00000407661
  • ENSP00000385193
  • ENST00000496972
  • ENSP00000444463
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
transcription factor
0.84
histone modification site profile
0.8
kinase perturbation
0.76
transcription factor binding site profile
0.76
trait
0.75


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 14.99   (req: < 5)
Gene RIFs: 3   (req: <= 3)
Antibodies: 234   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 14.99   (req: >= 5)
Gene RIFs: 3   (req: > 3)
Antibodies: 234   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Term: 1
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
No expression data found
Related Tools
Target Illumination GWAS Analytics (TIGA)
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TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (61)
SNTG2
Tbio
Novelty:  0.04056715
p_int:  0.999999996
p_ni:  4e-9
Score:  0.95
Data Source:  BioPlex,STRINGDB
SNTA1
Tbio
Novelty:  0.01668288
p_int:  0.999999996
p_ni:  3e-9
Score:  0.81
Data Source:  BioPlex,STRINGDB
SNTB1
Tbio
Novelty:  0.05324344
p_int:  0.999999965
p_ni:  3.5e-8
Score:  0.684
Data Source:  BioPlex,STRINGDB
SNTG1
Tbio
Novelty:  0.05608114
p_int:  0.999999845
p_ni:  1.55e-7
Score:  0.885
Data Source:  BioPlex,STRINGDB
DMD
Tclin
Novelty:  0.00025661
p_int:  0.999999787
p_ni:  2.11e-7
p_wrong:  2e-9
Score:  0.791
Data Source:  BioPlex,STRINGDB
FYCO1
Tbio
Novelty:  0.06181219
p_int:  0.999999696
p_ni:  3.04e-7
Data Source:  BioPlex
SNTB2
Tbio
Novelty:  0.05469501
p_int:  0.999997981
p_ni:  0.000002019
Score:  0.718
Data Source:  BioPlex,STRINGDB
UTRN
Tchem
Novelty:  0.0018541
p_int:  0.999997
p_ni:  0.000002999
p_wrong:  1e-9
Score:  0.72
Data Source:  BioPlex,STRINGDB
GOLGA4
Tbio
Novelty:  0.01363253
p_int:  0.999985009
p_ni:  0.000014991
Data Source:  BioPlex
IFT74
Tbio
Novelty:  0.07195266
p_int:  0.999379229
p_ni:  0.000620771
Data Source:  BioPlex
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (0)
No pathways found
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (2)
Find Similar Targets
Items per page:
10
1 – 1 of 1
GO Term
Evidence
Assigned by
Inferred from Electronic Annotation (IEA)
InterPro
Disease Associations ()
No disease associations found
GWAS Traits (21)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
BMI-adjusted waist circumference
1
7
7
88.7
waist-hip ratio
1
6
6
82.9
BMI-adjusted waist-hip ratio
2
4
5
82.6
waist circumference
1
4
4
76.9
3
2
2
1
67.5
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
BMI-adjusted waist circumference
7
88.7
waist-hip ratio
6
82.9
BMI-adjusted waist-hip ratio
5
82.6
waist circumference
4
76.9
2
1
67.5
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (12)
1 – 5 of 12
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
dystrobrevin beta
VGNC:232
459076
Macaque
dystrobrevin beta
696167
Mouse
MGI:1203728
13528
Rat
RGD:1309579
362715
Dog
dystrobrevin beta
482997
Species
Name
OMA
EggNOG
Inparanoid
Chimp
dystrobrevin beta
Macaque
dystrobrevin beta
Mouse
Rat
Dog
dystrobrevin beta
Publication Statistics
PubMed Score 14.99
PubMed score by year
PubTator Score 217.50
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title