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Tchem
DSTYK
Dual serine/threonine and tyrosine protein kinase

Protein Summary
Description
Acts as a positive regulator of ERK phosphorylation downstream of fibroblast growth factor-receptor activation (PubMed:23862974, PubMed:28157540). Involved in the regulation of both caspase-dependent apoptosis and caspase-independent cell death (PubMed:15178406). In the skin, it plays a predominant role in suppressing caspase-dependent apoptosis in response to UV stress in a range of dermal cell types (PubMed:28157540). This gene encodes a dual serine/threonine and tyrosine protein kinase which is expressed in multiple tissues. It is thought to function as a regulator of cell death. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Dec 2008]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000367161
  • ENSP00000356129
  • ENSG00000133059
  • ENST00000367162
  • ENSP00000356130
  • ENST00000615388
  • ENSP00000478016

Symbol
  • KIAA0472
  • RIP5
  • RIPK5
  • SGK496
  • RIP5
  • RIPK5
  • SPG23
  • CAKUT1
  • DustyPK
  • HDCMD38P
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
virus perturbation
0.95
molecular function
0.93
transcription factor binding site profile
0.93
microRNA
0.85
transcription factor
0.83


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 9.74   (req: < 5)
Gene RIFs: 4   (req: <= 3)
Antibodies: 166   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 9.74   (req: >= 5)
Gene RIFs: 4   (req: > 3)
Antibodies: 166   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 9
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 2
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (6)
Dark Kinase Knowledgebase
Thumbnail image for Dark Kinase Knowledgebase
The Dark Kinase Knowledgebase is an an online compendium of knowledge and experimental results of understudied kinases.
ProKinO
Thumbnail image for ProKinO
The ProKinO is a protein kinase-specific ontology, which provides a controlled vocabulary of terms, their hierarchy, and relationships unifying sequence, structure, function, mutation and pathway information on kinases.
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Protein-Protein Interactions (67)
IFT20
Tbio
Novelty:  0.03005088
p_int:  0.999749434
p_ni:  0.000250564
p_wrong:  3e-9
Data Source:  BioPlex
TFPI2
Tbio
Novelty:  0.00475383
p_int:  0.999661738
p_ni:  0.000338262
Data Source:  BioPlex
IL1R2
Tbio
Novelty:  0.00820359
p_int:  0.997271142
p_ni:  0.002728858
Data Source:  BioPlex
CD226
Tbio
Novelty:  0.00374102
p_int:  0.993135569
p_ni:  0.006864359
p_wrong:  7.2e-8
Data Source:  BioPlex
CDH13
Tbio
Novelty:  0.00389516
p_int:  0.981378687
p_ni:  0.018621313
Score:  0.151
Data Source:  BioPlex,STRINGDB
CTDSP1
Tchem
Family:  Enzyme
Novelty:  0.0231786
p_int:  0.981139915
p_ni:  0.018860085
Score:  0.232
Data Source:  BioPlex,STRINGDB
RAB2B
Tbio
Family:  Enzyme
Novelty:  0.18567584
p_int:  0.965994238
p_ni:  0.034005762
Score:  0.229
Data Source:  BioPlex,STRINGDB
DCTN1
Tbio
Novelty:  0.00494896
p_int:  0.965741372
p_ni:  0.034258628
Score:  0.187
Data Source:  BioPlex,STRINGDB
CD79B
Tclin
Novelty:  0.00227414
p_int:  0.962144499
p_ni:  0.037855501
p_wrong:  1e-9
Data Source:  BioPlex
GRPR
Tchem
Family:  GPCR
Novelty:  0.00282511
p_int:  0.96085584
p_ni:  0.03914416
Score:  0.155
Data Source:  BioPlex,STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (0)
No pathways found
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (13)
Find Similar Targets
Items per page:
10
1 – 4 of 4
GO Term
Evidence
Assigned by
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Inferred from Electronic Annotation (IEA)
UniProtKB-EC
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Disease Associations (null)
No disease associations found
GWAS Traits (33)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
mean platelet volume
7
10
10
99.8
reticulocyte count
7
4
7
97
platelet count
3
4
3
2.8
96.9
reticulocyte measurement
3
4
4
96.7
red blood cell distribution width
4
5
5
95.9
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
mean platelet volume
10
99.8
reticulocyte count
7
97
platelet count
3
2.8
96.9
reticulocyte measurement
4
96.7
red blood cell distribution width
5
95.9
Find similar targets by:
Orthologs (11)
1 – 5 of 11
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
dual serine/threonine and tyrosine protein kinase
VGNC:6785
457666
Macaque
dual serine/threonine and tyrosine protein kinase
664732
Mouse
MGI:1925064
213452
Rat
RGD:735051
304791
Dog
dual serine/threonine and tyrosine protein kinase
VGNC:54269
478942
Species
Name
OMA
EggNOG
Inparanoid
Chimp
dual serine/threonine and tyrosine protein kinase
Macaque
dual serine/threonine and tyrosine protein kinase
Mouse
Rat
Dog
dual serine/threonine and tyrosine protein kinase
Publication Statistics
PubMed Score 9.74
PubMed score by year
PubTator Score 5.60
PubTator score by year
Patents
Patents by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title