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Tbio
DSTN
Destrin

Protein Summary
Description
Actin-depolymerizing protein. Severs actin filaments (F-actin) and binds to actin monomers (G-actin). Acts in a pH-independent manner. The product of this gene belongs to the actin-binding proteins ADF family. This family of proteins is responsible for enhancing the turnover rate of actin in vivo. This gene encodes the actin depolymerizing protein that severs actin filaments (F-actin) and binds to actin monomers (G-actin). Two transcript variants encoding distinct isoforms have been identified for this gene. [provided by RefSeq, Jul 2008]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000246069
  • ENSP00000246069
  • ENSG00000125868
  • ENST00000474024
  • ENSP00000476975

Symbol
  • ACTDP
  • DSN
  • ADF
  • ACTDP
  • HEL32
  • bA462D18.2
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
disease perturbation
1
virus perturbation
1
transcription factor perturbation
0.94
transcription factor binding site profile
0.89
kinase perturbation
0.84


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 91.98   (req: < 5)
Gene RIFs: 11   (req: <= 3)
Antibodies: 349   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 91.98   (req: >= 5)
Gene RIFs: 11   (req: > 3)
Antibodies: 349   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 6
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (159)
ACTB
Tbio
Novelty:  0.00006048
Score:  0.912
Data Source:  STRINGDB
ACTG1
Tbio
Novelty:  0.00086444
Score:  0.905
Data Source:  STRINGDB
WDR1
Tbio
Novelty:  0.01524342
Score:  0.872
Data Source:  STRINGDB
TWF1
Tbio
Novelty:  0.03535316
Score:  0.846
Data Source:  STRINGDB
RPS6
Tbio
Novelty:  0.00122241
Score:  0.831
Data Source:  STRINGDB
RBM24
Tbio
Novelty:  0.04562076
Score:  0.827
Data Source:  STRINGDB
LIMK1
Tchem
Family:  Kinase
Novelty:  0.00349854
Score:  0.8
Data Source:  STRINGDB
TPM4
Tbio
Novelty:  0.00557194
Score:  0.794
Data Source:  STRINGDB
SSH1
Tbio
Family:  Enzyme
Novelty:  0.02079383
Score:  0.777
Data Source:  STRINGDB
LIMK2
Tchem
Family:  Kinase
Novelty:  0.0153308
Score:  0.772
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (118)
Find Similar Targets
Items per page:
1 – 5 of 118
Data Source
Name
Explore in Pharos
Explore in Source
WikiPathways
Androgen receptor signaling pathway
WikiPathways
Androgen receptor signaling pathway
WikiPathways
Androgen receptor signaling pathway
WikiPathways
Androgen receptor signaling pathway
WikiPathways
Androgen receptor signaling pathway
Name
Explore in Pharos
Explore in Source
Androgen receptor signaling pathway
Androgen receptor signaling pathway
Androgen receptor signaling pathway
Androgen receptor signaling pathway
Androgen receptor signaling pathway
Viral Interactions (0)
No viral interactions found
Disease Associations (null)
No disease associations found
GWAS Traits (20)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
apolipoprotein A 1 measurement
3
2
3
79.3
eosinophil count
3
3
3
78.7
high density lipoprotein cholesterol measurement
14
2
14
69.6
myeloperoxidase measurement
1
1
1
55
balding measurement
1
1
1
47.1
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
apolipoprotein A 1 measurement
3
79.3
eosinophil count
3
78.7
high density lipoprotein cholesterol measurement
14
69.6
myeloperoxidase measurement
1
55
balding measurement
1
47.1
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (11)
1 – 5 of 11
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
destrin, actin depolymerizing factor
VGNC:9839
458108
Macaque
destrin, actin depolymerizing factor
695969
Mouse
MGI:1929270
56431
Rat
RGD:1588366
502674
Dog
destrin, actin depolymerizing factor
VGNC:40111
477147
Species
Name
OMA
EggNOG
Inparanoid
Chimp
destrin, actin depolymerizing factor
Macaque
destrin, actin depolymerizing factor
Mouse
Rat
Dog
destrin, actin depolymerizing factor
Publication Statistics
PubMed Score 91.98
PubMed score by year
PubTator Score 304.08
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title