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Tbio
DST
Dystonin

Protein Summary
Description
Cytoskeletal linker protein. Acts as an integrator of intermediate filaments, actin and microtubule cytoskeleton networks. Required for anchoring either intermediate filaments to the actin cytoskeleton in neural and muscle cells or keratin-containing intermediate filaments to hemidesmosomes in epithelial cells. The proteins may self-aggregate to form filaments or a two-dimensional mesh. Regulates the organization and stability of the microtubule network of sensory neurons to allow axonal transport. Mediates docking of the dynein/dynactin motor complex to vesicle cargos for retrograde axonal transport through its interaction with TMEM108 and DCTN1 (By similarity). Isoform 3: plays a structural role in the assembly of hemidesmosomes of epithelial cells; anchors keratin-containing intermediate filaments to the inner plaque of hemidesmosomes. Required for the regulation of keratinocyte polarity and motility; mediates integrin ITGB4 regulation of RAC1 activity. Isoform 6: required for bundl ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000244364
  • ENSP00000244364
  • ENSG00000151914
  • ENST00000370765
  • ENSP00000359801
  • ENST00000370788
  • ENSP00000359824
  • ENST00000439203
  • ENSP00000404924

Symbol
  • BP230
  • BP240
  • BPAG1
  • DMH
  • DT
  • KIAA0728
  • DT
  • BPA
  • DMH
  • BP240
  • BPAG1
  • EBSB2
  • HSAN6
  • MACF2
  • CATX15
  • CATX-15
  • D6S1101
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
protein domain
1
PubMedID
0.99
transcription factor perturbation
0.99
interacting protein
0.95
cellular component
0.92


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 560.71   (req: < 5)
Gene RIFs: 27   (req: <= 3)
Antibodies: 163   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 560.71   (req: >= 5)
Gene RIFs: 27   (req: > 3)
Antibodies: 163   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 20
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0