Protein Summary
Component of intercellular desmosome junctions. Involved in the interaction of plaque proteins and intermediate filaments mediating cell-cell adhesion. Coordinates the transition from proliferation to differentiation in hair follicle keratinocytes (By similarity). This gene encodes a member of the desmoglein subgroup of desmosomal cadherins. The encoded preproprotein is proteolytically processed to generate the mature protein. This protein is a transmembrane component of desmosomes and may play a role in cell-cell adhesion in epithelial cells. Mutations in the gene are associated with localized autosomal recessive hypotrichosis and monilethrix, characterized by impaired hair growth. [provided by RefSeq, May 2016]
- ENST00000308128
- ENSP00000311859
- ENSG00000175065
- ENST00000359747
- ENSP00000352785
- CDHF13
- LAH
- HYPT6
- CDGF13
- CDHF13
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
---|---|---|---|
protein domain | 0.92 | ||
interacting protein | 0.68 | ||
cell line | 0.61 | ||
phenotype | 0.46 | ||
metabolite | 0.45 | ||
Protein Classes
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 57.02 (req: < 5)
Gene RIFs: 11 (req: <= 3)
Antibodies: 100 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 57.02 (req: >= 5)
Gene RIFs: 11 (req: > 3)
Antibodies: 100 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 6
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligand: 0
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
Related Tools

TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.

GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.

GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.

ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
Active Ligands (0)
Protein-Protein Interactions (126)
RAB11B
Family: Enzyme
Novelty: 0.00557558
p_int: 0.999877839
p_ni: 0.000122146
p_wrong: 1.4e-8
Data Source: BioPlex
FBXO3
Novelty: 0.01701102
p_int: 0.999808213
p_ni: 0.000191778
p_wrong: 1e-8
Data Source: BioPlex
RPN2
Family: Enzyme
Novelty: 0.01796569
p_int: 0.999698165
p_ni: 0.000301834
Data Source: BioPlex
LAIR2
Novelty: 0.06117644
p_int: 0.998956913
p_ni: 0.001043084
p_wrong: 4e-9
Data Source: BioPlex
PYHIN1
Novelty: 0.06662677
p_int: 0.998725124
p_ni: 0.001274862
p_wrong: 1.4e-8
Data Source: BioPlex
OR51E2
Family: oGPCR
Novelty: 0.02435259
p_int: 0.998312709
p_ni: 0.001687269
p_wrong: 2.2e-8
Data Source: BioPlex
Nearest Tclin Targets
Pathways (51)
Reactome (3)
WikiPathways (48)
Click on a row in the table to change the structure displayed.
Data Source | Name | Explore in Pharos | Explore in Source | ||
---|---|---|---|---|---|
Reactome | Developmental Biology | ||||
Reactome | Formation of the cornified envelope | ||||
Reactome | Keratinization | ||||
Name | Explore in Pharos | Explore in Source | ||
---|---|---|---|---|
Developmental Biology | ||||
Formation of the cornified envelope | ||||
Keratinization | ||||
Viral Interactions (0)
Gene Ontology Terms (10)
Functions (1)
Components (4)
Processes (5)
GO Term | Evidence | Assigned by | ||
---|---|---|---|---|
Inferred from Electronic Annotation (IEA) | Ensembl | |||
Disease Associations ()
GWAS Traits (3)
Items per page:
1 – 3 of 3
GWAS Trait | EFO ID | Study Count | SNP Count | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
---|---|---|---|---|---|---|---|---|---|
susceptibility to vaginal yeast infection measurement | 1 | 1 | 1 | 66.8 | |||||
vitamin D measurement | 3 | 2 | 3 | 57.1 | |||||
1 | 1 | 0 | 5.5 | 14.2 | |||||
Items per page:
1 – 3 of 3
GWAS Trait | EFO ID | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
---|---|---|---|---|---|---|---|
susceptibility to vaginal yeast infection measurement | 1 | 66.8 | |||||
vitamin D measurement | 3 | 57.1 | |||||
0 | 5.5 | 14.2 | |||||
Find similar targets by:
IDG Resources
Orthologs (8)
1 – 5 of 8
Species | Name | Source ID | Gene ID | OMA | EggNOG | Inparanoid | ||
---|---|---|---|---|---|---|---|---|
Chimp | desmoglein 4 | VGNC:5161 | 743297 | |||||
Macaque | desmoglein 4 | 713015 | ||||||
Mouse | MGI:2661061 | 16769 | ||||||
Rat | RGD:735015 | 291754 | ||||||
Dog | desmoglein 4 | VGNC:40108 | 612592 | |||||
Species | Name | OMA | EggNOG | Inparanoid | ||
---|---|---|---|---|---|---|
Chimp | desmoglein 4 | |||||
Macaque | desmoglein 4 | |||||
Mouse | ||||||
Rat | ||||||
Dog | desmoglein 4 | |||||
Publication Statistics
PubMed Score 57.02
PubMed score by year
PubTator Score 39.87
PubTator score by year
Related Publications
Text Mined References (23)
GeneRif Annotations (11)
Items per page:
0 of 0
PMID | Year | Title |
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