Protein Summary
Component of intercellular desmosome junctions. Involved in the interaction of plaque proteins and intermediate filaments mediating cell-cell adhesion. This gene encodes a member of the desmoglein family and cadherin cell adhesion molecule superfamily of proteins. Desmogleins are calcium-binding transmembrane glycoprotein components of desmosomes, cell-cell junctions between epithelial, myocardial, and other cell types. The encoded preproprotein is proteolytically processed to generate the mature glycoprotein. This gene is present in a gene cluster with other desmoglein gene family members on chromosome 18. The encoded protein has been identified as the autoantigen of the autoimmune blistering disease pemphigus vulgaris. [provided by RefSeq, Jan 2016]
- ENST00000257189
- ENSP00000257189
- ENSG00000134757
- CDHF6
- PVA
- CDHF6
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
|---|---|---|---|
protein domain | 0.92 | ||
biological term | 0.71 | ||
virus perturbation | 0.64 | ||
cellular component | 0.63 | ||
gene perturbation | 0.59 | ||
Protein Classes
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 563.72 (req: < 5)
Gene RIFs: 69 (req: <= 3)
Antibodies: 644 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 563.72 (req: >= 5)
Gene RIFs: 69 (req: > 3)
Antibodies: 644 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 4
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligand: 0
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drug: 0
Expression Data (0 Tissues)
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
Active Ligands (0)
Protein-Protein Interactions (81)
HSF2
Family: TF
Novelty: 0.06458223
p_int: 0.999962372
p_ni: 0.000019666
p_wrong: 0.000017962
Data Source: BioPlex
FRMD1
Novelty: 0.96833141
p_int: 0.999653791
p_ni: 0.000061192
p_wrong: 0.000285018
Score: 0.223
Data Source: BioPlex,STRINGDB
OAZ3
Family: Enzyme
Novelty: 0.02374168
p_int: 0.858741311
p_ni: 0.00047611
p_wrong: 0.140782579
Score: 0.224
Data Source: BioPlex,STRINGDB
Nearest Tclin Targets
Pathways (8)
Reactome (8)
Click on a row in the table to change the structure displayed.
Data Source | Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|---|
Reactome | Apoptosis | ||||
Reactome | Apoptotic cleavage of cell adhesion proteins | ||||
Reactome | Apoptotic cleavage of cellular proteins | ||||
Reactome | Apoptotic execution phase | ||||
Reactome | Developmental Biology | ||||
Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|
Apoptosis | ||||
Apoptotic cleavage of cell adhesion proteins | ||||
Apoptotic cleavage of cellular proteins | ||||
Apoptotic execution phase | ||||
Developmental Biology | ||||
Viral Interactions (0)
Gene Ontology Terms (10)
Functions (1)
Components (6)
Processes (3)
GO Term | Evidence | Assigned by | ||
|---|---|---|---|---|
Inferred from Electronic Annotation (IEA) | InterPro | |||
Disease Associations (null)
GWAS Traits (1)
Items per page:
1 – 1 of 1
GWAS Trait | EFO ID | Study Count | SNP Count | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
|---|---|---|---|---|---|---|---|---|---|
1 | 1 | 0 | 5.5 | 14.2 | |||||
Items per page:
1 – 1 of 1
GWAS Trait | EFO ID | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
|---|---|---|---|---|---|---|---|
0 | 5.5 | 14.2 | |||||
Find similar targets by:
IDG Resources
Orthologs (8)
1 – 5 of 8
Species | Name | Source ID | Gene ID | OMA | EggNOG | Inparanoid | ||
|---|---|---|---|---|---|---|---|---|
Chimp | desmoglein 3 | VGNC:5160 | 468511 | |||||
Macaque | desmoglein 3 | 705685 | ||||||
Mouse | MGI:99499 | 13512 | ||||||
Rat | RGD:1592103 | 291752 | ||||||
Dog | desmoglein 3 | VGNC:40107 | 403470 | |||||
Species | Name | OMA | EggNOG | Inparanoid | ||
|---|---|---|---|---|---|---|
Chimp | desmoglein 3 | |||||
Macaque | desmoglein 3 | |||||
Mouse | ||||||
Rat | ||||||
Dog | desmoglein 3 | |||||
Publication Statistics
PubMed Score 563.72
PubMed score by year
PubTator Score 439.40
PubTator score by year
Related Publications
Text Mined References (102)
GeneRif Annotations (69)
Items per page:
0 of 0
PMID | Year | Title |
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