You are using an outdated browser. Please upgrade your browser to improve your experience.

Tbio
DSE
Dermatan-sulfate epimerase

Protein Summary
Description
Converts D-glucuronic acid to L-iduronic acid (IdoUA) residues. The protein encoded by this gene is a tumor-rejection antigen. It is localized to the endoplasmic reticulum and functions to convert D-glucuronic acid to L-iduronic acid during the biosynthesis of dermatan sulfate. This antigen possesses tumor epitopes capable of inducing HLA-A24-restricted and tumor-specific cytotoxic T lymphocytes in cancer patients and may be useful for specific immunotherapy. Mutations in this gene cause inmusculocontractural Ehlers-Danlos syndrome. Alternative splicing results in multiple transcript variants. A related pseudogene has been identified on chromosome 9, and a paralogous gene exists on chromosome 18. [provided by RefSeq, Apr 2016]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000331677
  • ENSP00000332151
  • ENSG00000111817
  • ENST00000452085
  • ENSP00000404049
  • ENST00000644252
  • ENSP00000494147

Symbol
  • SART2
  • DSEP
  • DSEPI
  • SART2
  • EDSMC2
  • SART-2
  • DS-epi1
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
transcription factor binding site profile
0.76
gene perturbation
0.71
transcription factor
0.69
transcription factor perturbation
0.68
cellular component
0.64


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 40.03   (req: < 5)
Gene RIFs: 5   (req: <= 3)
Antibodies: 74   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 40.03   (req: >= 5)
Gene RIFs: 5   (req: > 3)
Antibodies: 74   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 4
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
No expression data found
Related Tools
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (86)
SYNE4
Tbio
Novelty:  0.0739848
p_int:  0.998578851
p_ni:  0.001421016
p_wrong:  1.33e-7
Data Source:  BioPlex
HLA-DPA1
Tbio
Novelty:  0.01080446
p_int:  0.997277915
p_ni:  0.002717448
p_wrong:  0.000004637
Data Source:  BioPlex
HLA-DRA
Tbio
Novelty:  0.0060214
p_int:  0.99705408
p_ni:  0.002911553
p_wrong:  0.000034367
Data Source:  BioPlex
MGAT4C
Tdark
Family:  Enzyme
Novelty:  0.19680806
p_int:  0.996578209
p_ni:  0.003421318
p_wrong:  4.73e-7
Data Source:  BioPlex
PICK1
Tbio
Novelty:  0.0058265
p_int:  0.981990422
p_ni:  0.017323291
p_wrong:  0.000686287
Data Source:  BioPlex
CD79B
Tclin
Novelty:  0.00227414
p_int:  0.956528849
p_ni:  0.002254616
p_wrong:  0.041216535
Data Source:  BioPlex
CHRNA3
Tclin
Family:  IC
Novelty:  0.00659767
p_int:  0.954791284
p_ni:  0.007443593
p_wrong:  0.037765122
Score:  0.307
Data Source:  BioPlex,STRINGDB
SLC7A14
Tbio
Family:  Transporter
Novelty:  0.1613451
p_int:  0.787900044
p_ni:  0.003355163
p_wrong:  0.208744793
Data Source:  BioPlex
HTR3A
Tclin
Family:  IC
Novelty:  0.00217443
p_int:  0.780143652
p_ni:  0.016706001
p_wrong:  0.203150347
Data Source:  BioPlex
NRG1
Tbio
Novelty:  0.00095246
p_int:  0.761904544
p_ni:  0.016346669
p_wrong:  0.221748787
Score:  0.209
Data Source:  BioPlex,STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (10)
Chondroitin sulfate/dermatan sulfate metabolism (R-HSA-1793185)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 5 of 5
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Chondroitin sulfate/dermatan sulfate metabolism
Reactome
Dermatan sulfate biosynthesis
Reactome
Glycosaminoglycan metabolism
Reactome
Metabolism
Reactome
Metabolism of carbohydrates
Name
Explore in Pharos
Explore in Source
Chondroitin sulfate/dermatan sulfate metabolism
Dermatan sulfate biosynthesis
Glycosaminoglycan metabolism
Metabolism
Metabolism of carbohydrates
Viral Interactions (0)
No viral interactions found
Disease Associations ()
No disease associations found
GWAS Traits (8)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
platelet count
1
1
1
61.4
mean platelet volume
2
1
2
56.6
BMI-adjusted hip circumference
2
2
2
49.2
total cholesterol measurement
1
1
1
44.2
1
1
0
2
27.9
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
platelet count
1
61.4
mean platelet volume
2
56.6
BMI-adjusted hip circumference
2
49.2
total cholesterol measurement
1
44.2
0
2
27.9
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (14)
1 – 5 of 14
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
dermatan sulfate epimerase
VGNC:2770
462957
Macaque
dermatan sulfate epimerase
716054
Mouse
MGI:2443455
212898
Rat
RGD:1305079
365583
Dog
dermatan sulfate epimerase
476271
Species
Name
OMA
EggNOG
Inparanoid
Chimp
dermatan sulfate epimerase
Macaque
dermatan sulfate epimerase
Mouse
Rat
Dog
dermatan sulfate epimerase
Publication Statistics
PubMed Score 40.03
PubMed score by year
PubTator Score 15.08
PubTator score by year
loading...
Related Publications
Items per page:
0 of 0
PMID
Year
Title