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Tbio
DSCC1
Sister chromatid cohesion protein DCC1

Protein Summary
Description
Loads PCNA onto primed templates regulating velocity, spacing and restart activity of replication forks. May couple DNA replication to sister chromatid cohesion through regulation of the acetylation of the cohesin subunit SMC3. CHTF18 (MIM 613201), CHTF8 (MIM 613202), and DSCC1 are components of an alternative replication factor C (RFC) (see MIM 600404) complex that loads PCNA (MIM 176740) onto DNA during S phase of the cell cycle (Merkle et al., 2003 [PubMed 12766176]; Bermudez et al., 2003 [PubMed 12930902]).[supplied by OMIM, Dec 2009]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000313655
  • ENSP00000322180
  • ENSG00000136982

Symbol
  • DCC1
  • DCC1
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
histone modification site profile
0.92
transcription factor perturbation
0.74
transcription factor binding site profile
0.65
molecular function
0.63
protein complex
0.58


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 22.92   (req: < 5)
Gene RIFs: 4   (req: <= 3)
Antibodies: 190   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 22.92   (req: >= 5)
Gene RIFs: 4   (req: > 3)
Antibodies: 190   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 6
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (210)
RFC4
Tbio
Novelty:  0.03232586
p_int:  1
Score:  0.999
Data Source:  BioPlex,STRINGDB
RFC5
Tbio
Novelty:  0.03987481
p_int:  0.999999998
p_ni:  2e-9
Score:  0.998
Data Source:  BioPlex,STRINGDB
P0CG13
Tbio
Novelty:  0.15007488
p_int:  0.999999993
p_ni:  6e-9
p_wrong:  1e-9
Score:  0.996
Data Source:  BioPlex,STRINGDB
CHTF18
Tbio
Novelty:  0.02470494
p_int:  0.999994746
p_ni:  0.000005254
Score:  0.999
Data Source:  BioPlex,STRINGDB
RFC2
Tbio
Novelty:  0.02088405
p_int:  0.998948701
p_ni:  0.001051299
Score:  0.996
Data Source:  BioPlex,STRINGDB
RFC3
Tbio
Novelty:  0.02712951
p_int:  0.997905881
p_ni:  0.002094119
Score:  0.998
Data Source:  BioPlex,STRINGDB
TAF8
Tbio
Novelty:  0.01056638
p_int:  0.975577829
p_ni:  0.024422171
Score:  0.174
Data Source:  BioPlex,STRINGDB
P4HA2
Tbio
Family:  Enzyme
Novelty:  0.02097718
p_int:  0.963166189
p_ni:  0.036833811
Data Source:  BioPlex
CDIPT
Tbio
Family:  Enzyme
Novelty:  0.00560887
p_int:  0.958300611
p_ni:  0.041699389
Score:  0.188
Data Source:  BioPlex,STRINGDB
GTF2F1
Tbio
Novelty:  0.02118098
p_int:  0.957990499
p_ni:  0.042009501
Data Source:  BioPlex
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (10)
Find Similar Targets
Items per page:
10
1 – 1 of 1
GO Term
Evidence
Assigned by
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Disease Associations (null)
No disease associations found
GWAS Traits (3)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
1
1
0
1.2
49.5
reticulocyte measurement
1
1
1
39.6
glomerular filtration rate
1
1
1
21.5
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
0
1.2
49.5
reticulocyte measurement
1
39.6
glomerular filtration rate
1
21.5
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (14)
1 – 5 of 14
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
DNA replication and sister chromatid cohesion 1
VGNC:11965
464356
Macaque
DNA replication and sister chromatid cohesion 1
702520
Mouse
MGI:1919357
72107
Rat
RGD:1561749
299933
Dog
DNA replication and sister chromatid cohesion 1
VGNC:51769
609036
Species
Name
OMA
EggNOG
Inparanoid
Chimp
DNA replication and sister chromatid cohesion 1
Macaque
DNA replication and sister chromatid cohesion 1
Mouse
Rat
Dog
DNA replication and sister chromatid cohesion 1
Publication Statistics
PubMed Score 22.92
PubMed score by year
PubTator Score 6.55
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title