Tbio DSC3 Desmocollin-3

Protein Summary

Description

Component of intercellular desmosome junctions. Involved in the interaction of plaque proteins and intermediate filaments mediating cell-cell adhesion. May contribute to epidermal cell positioning (stratification) by mediating differential adhesiveness between cells that express different isoforms. The protein encoded by this gene is a calcium-dependent glycoprotein that is a member of the desmocollin subfamily of the cadherin superfamily. These desmosomal family members, along with the desmogleins, are found primarily in epithelial cells where they constitute the adhesive proteins of the desmosome cell-cell junction and are required for cell adhesion and desmosome formation. The desmosomal family members are arranged in two clusters on chromosome 18, occupying less than 650 kb combined. Mutations in this gene are a cause of hypotrichosis and recurrent skin vesicles disorder. The protein can act as an autoantigen in pemphigus diseases, and it is also considered to be a biomarker for some cancers. Alternative splicing of this gene results in multiple transcript variants. [provided by RefSeq, Apr 2014]

Uniprot Accession IDs

• Q14574
• A6NN35
• Q14200
• Q9HAZ9

Gene Name

• DSC3

Ensembl ID

• ENST00000360428
• ENSP00000353608
• ENSG00000134762
• ENST00000434452
• ENSP00000392068

Symbol

• CDHF3
• DSC4
• DSC
• DSC1
• DSC2
• DSC4
• CDHF3
• HT-CP

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
protein domain	0.92
virus perturbation	0.83
microRNA	0.7
cell type or tissue	0.69
gene perturbation	0.55

Protein Classes

PANTHER Classes

Protein / Cell Junction Protein / Desmocollin-3

Protein / Cell Adhesion Molecule / Cadherin / Desmocollin-3

DTO Classes

Protein / Cell Adhesion / Cadherin / Desmocollin-3

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 375.44   (req: < 5)

Gene RIFs: 26   (req: <= 3)

Antibodies: 216   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 375.44   (req: >= 5)

Gene RIFs: 26   (req: > 3)

Antibodies: 216   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 8

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0