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Tbio
DRP2
Dystrophin-related protein 2

Protein Summary
Description
Required for normal myelination and for normal organization of the cytoplasm and the formation of Cajal bands in myelinating Schwann cells. Required for normal PRX location at appositions between the abaxonal surface of the myelin sheath and the Schwann cell plasma membrane. Possibly involved in membrane-cytoskeleton interactions of the central nervous system. Members of the dystrophin family of proteins perform a critical role in the maintenance of membrane-associated complexes at points of intercellular contact in vertebrate cells. The protein encoded by this gene is predicted to resemble certain short C-terminal isoforms of dystrophin and dystrophin-related protein 1 (DRP1 or utrophin). DRP2 is expressed principally in the brain and spinal cord. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jan 2010]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000395209
  • ENSP00000378635
  • ENSG00000102385
  • ENST00000402866
  • ENSP00000385038
  • ENST00000538510
  • ENSP00000441051
  • ENST00000541709
  • ENSP00000444752

Symbol
  • DRP-2
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
protein domain
0.97
cell type or tissue
0.71
microRNA
0.71
virus perturbation
0.59
transcription factor
0.49


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 9.19   (req: < 5)
Gene RIFs: 1   (req: <= 3)
Antibodies: 56   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 9.19   (req: >= 5)
Gene RIFs: 1   (req: > 3)
Antibodies: 56   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 3
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (3)
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (29)
PRX
Tbio
Novelty:  0.01867283
Score:  0.967
Data Source:  STRINGDB
DPYSL2
Tbio
Family:  Enzyme
Novelty:  0.00374969
Score:  0.749
Data Source:  STRINGDB
RAB11FIP4
Tbio
Novelty:  0.13545871
Score:  0.73
Data Source:  STRINGDB
DAG1
Tbio
Family:  Enzyme
Novelty:  0.00149278
Score:  0.725
Data Source:  STRINGDB
MAP7D3
Tbio
Novelty:  0.10723742
Score:  0.658
Data Source:  STRINGDB
DTNA
Tbio
Novelty:  0.01165754
Score:  0.649
Data Source:  STRINGDB
RAB11FIP3
Tbio
Novelty:  0.07915085
Score:  0.581
Data Source:  STRINGDB
DPP3
Tbio
Family:  Enzyme
Novelty:  0.00763153
Score:  0.572
Data Source:  STRINGDB
FHL1
Tbio
Novelty:  0.01549633
Score:  0.571
Data Source:  STRINGDB
ADGRG4
Tdark
Family:  GPCR
Novelty:  0.39161511
Score:  0.558
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (0)
No pathways found
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (9)
Find Similar Targets
Items per page:
10
1 – 1 of 1
GO Term
Evidence
Assigned by
Inferred from Electronic Annotation (IEA)
InterPro
Disease Associations (null)
No disease associations found
GWAS Traits (0)
No GWAS traits found
IDG Resources
No IDG generated resources found
Orthologs (13)
1 – 5 of 13
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
dystrophin related protein 2
VGNC:1387
465758
Macaque
dystrophin related protein 2
702655
Mouse
MGI:107432
13497
Rat
RGD:621750
66027
Dog
dystrophin related protein 2
VGNC:54135
480984
Species
Name
OMA
EggNOG
Inparanoid
Chimp
dystrophin related protein 2
Macaque
dystrophin related protein 2
Mouse
Rat
Dog
dystrophin related protein 2
Publication Statistics
PubMed Score 9.19
PubMed score by year
PubTator Score 16.21
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title